The Genetic Polymorphisms in the MIR17HG Gene Are Associated with the Risk of Head and Neck Squamous Cell Carcinoma in the Chinese Han Population
Table 6
The relationship of MIR17HG variants with nasopharyngeal SCC and thyroid SCC risk.
SNP ID
Allele/genotype
Nasopharyngeal SCC
Thyroid SCC
Case
Control
OR (95% CI)
Case
Control
OR (95% CI)
rs75267932
A
135
943
1
714
943
1
G
19
123
1.08 (0.64-1.81)
0.773
82
123
0.88 (0.66-1.18)
0.399
AA
59
417
1
323
417
1
GA
17
109
1.24 (0.68-2.24)
0.485
68
109
0.79 (0.56-1.11)
0.173
GG
1
7
0.87 (0.10-7.39)
0.898
7
7
1.37 (0.47-3.98)
0.562
AG-GG
18
116
1.21 (0.68-2.16)
0.524
75
116
0.82 (0.59-1.14)
0.247
rs72640334
C
132
973
1
713
973
1
A
18
91
1.46 (0.85-2.50)
0.167
81
91
1.22 (0.89-1.66)
0.225
CC
58
443
1
321
443
1
CA
16
87
1.29 (0.70-2.37)
0.419
71
87
1.15 (0.81-1.63)
0.435
AA
1
2
3.65 (0.29-46.40)
0.318
5
2
3.09 (0.58-16.38)
0.184
CA-AA
17
89
1.34 (0.73-2.43)
0.342
76
89
1.20 (0.85-1.68)
0.306
rs7336610
T
70
544
1
408
544
1
C
84
520
1.26 (0.89-1.76)
0.188
388
520
0.99 (0.83-1.20)
0.956
TT
14
143
1
102
143
1
TC
42
258
1.72 (0.90-3.29)
0.102
204
258
1.09 (0.79-1.50)
0.594
CC
21
131
1.45 (0.70-3.01)
0.319
92
131
1.00 (0.69-1.46)
0.986
TC-CC
63
389
1.62 (0.87-3.01)
0.127
296
389
1.06 (0.79-1.43)
0.697
rs7318578
A
102
769
1
573
769
1
C
52
295
1.33 (0.93-1.91)
0.121
223
295
1.02 (0.83-1.25)
0.890
AA
32
278
1
202
278
1
CA
38
213
1.46 (0.88-2.44)
0.147
169
213
1.10 (0.84-1.45)
0.494
CC
7
41
1.36 (0.55-3.35)
0.503
27
41
0.89 (0.53-1.50)
0.664
AC-CC
45
254
1.45 (0.88-2.37)
0.144
196
254
1.07 (0.82-1.39)
0.632
rs17735387
G
122
856
1
634
856
1
A
32
210
1.07 (0.70-1.62)
0.754
162
210
1.04 (0.83-1.31)
0.728
GG
48
345
1
253
345
1
GA
26
166
1.14 (0.68-1.93)
0.621
128
166
1.06 (0.79-1.40)
0.708
AA
3
22
0.88 (0.25-3.10)
0.843
17
22
1.11 (0.57-2.14)
0.762
GA-AA
29
188
1.11 (0.67-1.83)
0.692
145
188
1.06 (0.81-1.40)
0.667
rs1428
A
70
546
1
412
546
1
C
84
520
1.26 (0.90-1.77)
0.181
384
520
0.98 (0.81-1.18)
0.818
AA
14
144
1
106
144
1
CA
42
258
1.73 (0.90-3.31)
0.099
200
258
1.03 (0.75-1.42)
0.838
CC
21
131
1.46 (0.70-3.02)
0.314
92
131
0.97 (0.67-1.41)
0.878
AC-CC
63
389
1.63 (0.88-3.02)
0.123
292
389
1.01 (0.75-1.36)
0.933
Nasopharyngeal SCC: nasopharyngeal squamous cell carcinoma; thyroid SCC: thyroid squamous cell carcinoma. values were calculated by unconditional logistic regression analysis with adjustment for age and gender. indicates statistical significance. Highlighted in bold indicates the significant association between SNPs and HNSCC risk.
