The Genetic Polymorphisms in the MIR17HG Gene Are Associated with the Risk of Head and Neck Squamous Cell Carcinoma in the Chinese Han Population

Table 7

False-positive report probability analysis for the significant findings between MIR17HG variants and HNSCC risk.

Genotype and variables	OR (95% CI)	value^a	Statistical power^b	Prior probability
				0.25	0.1	0.01	0.001	0.0001
III-IV
rs17735387 G>A
GA vs. GG	0.34 (0.12-0.95)	0.040	0.308	0.192^c	0.416	0.887	0.988	0.999
GA-AA vs. GG	0.38 (0.15-0.97)	0.042	0.329	0.205	0.436	0.895	0.988	0.999
Men
rs7336610 T>C
TC vs. TT	1.77 (1.09-2.86)	0.021	0.487	0.106^c	0.262	0.796	0.975	0.997
TC-CC vs. TT	1.64 (1.04-2.57)	0.032	0.031	0.156^c	0.357	0.859	0.984	0.998
rs1428 A>C
CA vs. AA	1.73 (1.07-2.81)	0.025	0.410	0.138^c	0.325	0.841	0.982	0.998
AC-CC vs. AA	1.63 (1.04-2.56)	0.035	0.034	0.169^c	0.379	0.870	0.985	0.999

HNSCC: head and neck squamous cell carcinoma. value^a was calculated by unconditional logistic regression analysis with adjustment for age and gender. Statistical power^b was calculated using the number of observations in the subgroup and the OR and values in this table. ^cThe level of false-positive report probability threshold was set at 0.2, and noteworthy findings are presented.