An Inhibitor of DRP1 (Mdivi-1) Alleviates LPS-Induced Septic AKI by Inhibiting NLRP3 Inflammasome Activation

Figure 1

Mdivi-1 can alleviate kidney injury in mice. (a) Serum creatinine level in the vehicle control group (), vehicle Mdivi-1 group (), S-AKI control group (), and S-AKI+Mdivi-1 treatment group (). (b) Renal tubular injury score. The higher the score, the more severe the renal tubular injury. mice in each group. (c) HE staining of the renal cortex observed under a light microscope (40x magnification). mice in each group. (d) Western blot analysis of the DRP1 expression in the renal cortex. (e) DRP1 expression level in mitochondria after different treatments ( for each group).The data are presented as . versus control-treated mouse group. ^# versus LPS-induced S-AKI group ().

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