Trifolium Flavonoids Overcome Gefitinib Resistance of Non-Small-Cell Lung Cancer Cell by Suppressing ERK and STAT3 Signaling Pathways

Figure 2

TF potentiated gefitinib-induced apoptosis in PC-9R cells. (a) PC-9R cells were treated with vehicle or 17 μM gefitinib and then treated alone or combine with 20 μg/ml or 30 μg/ml TF for 24 h. The cells were then stained with Annexin V-FITC and PI and analyzed by flow cytometry. (b) Apoptosis was quantified and presented. Data were presented by for three separate experiments. vs. control, vs. control.

(a)

(b)