Porcupine Inhibitor LGK974 Downregulates the Wnt Signaling Pathway and Inhibits Clear Cell Renal Cell Carcinoma

Figure 3

LGK974 kills ccRCC cells in a concentration- and time-dependent manner. (a) CCK8 assays were used to detect the difference in the viability of 786-O cells after 48, 72, and 96 h of treatment with different concentrations of LGK974. (b) CCK8 assays were used to detect the difference in the viability of ACHN cells after 48, 72, and 96 h of treatment with different concentrations of LGK974. (c) CCK8 assays were used to detect cell viability of 786-O cells at different times using the same concentration of LGK974 (10 μM, 15 μM, or 20 μM). (d) CCK8 assays were used to detect cell viability of ACHN cells at different times using the same concentration of LGK974 (10 μM, 15 μM, or 20 μM) ; .

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