Tanshinone IIA Alleviates CCL2-Induced Leaning memory and Cognition Impairment in Rats: A Potential Therapeutic Approach for HIV-Associated Neurocognitive Disorder

Figure 2

Effect of Tanshinone IIA on learning and memory deficits in CCL2-induced rats. (a) Escape latency tendency of five consecutive days’ test. (b) The swimming speed among the groups. As shown, the speed was not different among the groups. (c) Escape latency of finding the hidden platform in the probe trial. Tan IIA treatment groups (Tan IIA(L): 25 mg/kg, Tan IIA(M): 50 mg/kg; Tan IIA(H): 75 mg/kg) spent less time to find hidden platform compared with the model group. (d) Swimming distance of finding the hidden platform in the probe trial. The Tan IIA treatment groups showed a significantly shorter distance to arrive platform. (e) The number of platform crossings in the probe test. All data are expressed as the mean ± SEM (n = 8, , , and versus model; , versus sham).

(a)

(b)

(c)

(d)

(e)