Tanshinone IIA Alleviates CCL2-Induced Leaning memory and Cognition Impairment in Rats: A Potential Therapeutic Approach for HIV-Associated Neurocognitive Disorder

<div>Effects of Tanshinone IIA on IL-1<i>β</i> and IL-6 mRNA expression in the hippocampus of CCL2-treated rats. Quantitative real-time PCR analysis of messenger (m) RNA levels. Relative expression of (a) IL-1<i>β</i>mRNA and (b) IL-6mRNA. qPCR analysis showed increased expression of IL-1<i>β</i> and IL-6 mRNA in the hippocampus of model rats. This result showing that Tanshinone IIA (Tan IIA(L): 25 mg/kg, Tan IIA(M): 50 mg/kg; Tan IIA(H): 75 mg/kg) significantly decreased the expression of IL-1<i>β</i> and IL-6 mRNA in model group rat. The experiments were repeated three times independently. 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BioMed Research International

fig6

Figure 6

Figure 6: Tanshinone IIA Alleviates CCL2-Induced Leaning memory and Cognition Impairment in Rats: A Potential Therapeutic Approach for HIV-Associated Neurocognitive Disorder 

Figure 6 | Tanshinone IIA Alleviates CCL2-Induced Leaning memory and Cognition Impairment in Rats: A Potential Therapeutic Approach for HIV-Associated Neurocognitive Disorder 