Tanshinone IIA Alleviates CCL2-Induced Leaning memory and Cognition Impairment in Rats: A Potential Therapeutic Approach for HIV-Associated Neurocognitive Disorder

Figure 7

Effect of Tan IIA on the hippocampal neuron damage in the hippocampus induced by CCL2. The CCL2 induces neuron damage and cell loss in the hippocampal CA1 regions, and the phenomenon can be rescued by Tan IIA. The hippocampus Nissl staining analysis was performed after the end of the novel object recognition test (Tan IIA(L):25 mg/kg, Tan IIA(M): 50 mg/kg; Tan IIA(H): 75 mg/kg). (a) Control. (b) Sham. (c) Model. (d) Memantine. (e) Tan IIA(L). (f) Tan IIA(M). (g) Tan IIA(H).

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