Improved Landmark Dynamic Prediction Model to Assess Cardiovascular Disease Risk in On-Treatment Blood Pressure Patients: A Simulation Study and Post Hoc Analysis on SPRINT Data

Table 5

Static and dynamic effect of SBP on cardiovascular event.

Variables	Simple Cox		LM		LFM
	HR	value	HR	value	HR	value
Age at enrolment day, yr	1.051	<0.001	1.018	<0.001	1.022	<0.001
Gender (female)	0.691	<0.001	1.019	0.164	0.843	0.291
TCH (mmol/L)	1.001	<0.001	1.001	0.163	1.000	0.582
HDL-C (mmol/L)	0.986	<0.001	0.991	0.001	0.987	0.023
Current smoker	1.820	<0.001	1.178	0.040	1.271	0.045
Treatment, intensive	0.720	<0.001	0.482	<0.001	0.475	<0.001
SBP (mmHg)	1.001	0.258	1.083	<0.001	1.109	<0.001
	—	—	0.996	<0.001	0.839	<0.001
	—	—	0.966	<0.001	0.895	<0.001

LM = landmark model; LFM = landmark frailty model; HR = hazard ratio; TCH = total cholesterol; HDL-C = high-density lipoprotein; SBP = systolic blood pressure.