Liraglutide Attenuates Nonalcoholic Fatty Liver Disease by Modulating Gut Microbiota in Rats Administered a High-Fat Diet

Figure 4

Seventy-eight operational taxonomic units (OTUs) altered upon liraglutide administration were significantly correlated with host metabolic parameters in accordance with Spearman’s correlation analysis. (a) Correlation between 76 OTUs and host metabolic parameters. Rows correspond to OTUs with identities shown on the left and columns correspond to metabolic parameters. Red and blue colors indicate positive and negative associations, respectively. Color intensity represents the degree of association between the OTU abundances and host parameters, as assessed via Spearman’s correlation analysis. Asterisks indicate significant associations. Taxonomic classification of the OTUs is shown on the right side. (b) Altered direction of 76 OTUs. Red and blue colors indicate the OTUs that were more and less abundant, respectively, in the H + L and control groups in comparison with the high-fat diet (HFD) group. The asterisk () represents OTUs whose level was altered via an HFD and then reversed significantly upon liraglutide administration.

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