Ultrashort Wave Combined with Human Umbilical Cord Mesenchymal Stem Cell (HUC-MSC) Transplantation Inhibits NLRP3 Inflammasome and Improves Spinal Cord Injury via MK2/TTP Signalling Pathway

Figure 5

MK2 upregulation blocks the microglia polarisation promoted by combination therapy: (a) iNOS and arg-1 expression levels detected using Western Blotting; (b) contents of inflammatory factors (IL-6 and IL-10) determined using ELISA; (c) Western Blotting was performed on to determine the expression levels of TTP, NLRP3, pro-IL-1β, and pro-IL-18; (d) contents of IL-1β and IL-18 in cellular supernatant were quantified with ELISA. “, #, &” indicated significant difference (), “” vs. Sham group, “#” vs. SCI group, and “&” vs. rats treated with monotherapies and combination therapy.

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