A Preclinical Porcine Model of Portal Vein Thrombosis in Liver Cirrhosis

Figure 1

PVT in a cirrhotic porcine model was successfully induced by the placement of a fibered coil into the main portal vein through a sheath introducer followed by the intravenous thrombin administration. (a) General features of representative liver specimens in healthy and cirrhotic pig models. (b) Representative image presenting pathological changes of the porcine model in normal, cirrhosis, and cirrhosis with PVT groups. (c) One representative image of PVT induction in cirrhosis. (d) CT examination of a filling defect on a portal venous phase showed the formation of thrombosis. (e) Organized thrombi adjacent to the intima of the portal vein. (f) Platelet aggregation (white arrow) adjoining the vessel in cirrhotic liver specimens was identified.

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