Analysis of Acrolein Exposure Induced Pulmonary Response in Seven Inbred Mouse Strains and Human Primary Bronchial Epithelial Cells Cultured at Air-Liquid Interface

Table 1

Fold change calculation of selected oxidative stress, proinflammatory, and tissue injury/repair markers in sham (clean air) in six mouse strains compared to one of the most sensitive mouse strains (BALB/BL6J) used in this study.

Expression markers	BALB/cByJ	C57/BL6J	129S1/SVLMJ	DBA/2J	C3H/HeJ	A/J	FVB/NJ
Oxidative stress
Hmox1	1	0.59	0.34	1.19	0.67	1.99	1.42
Nfkb1	1	0.95	1.37	0.53	1.15	0.46	1.17
Inflammation
Cxcl1	1	0.79	1.29	1.08	0.89	0.57	0.75
Cxcl2	1	0.69	0.59	0.94	1.08	1.16	1.23
IL-6	1	1.32	1.66	0.74	1.09	1.18	1.28
Tnf	1	1.1	0.92	0.82	0.69	1.04	0.91
Tissue injury/repair
Mmp9	1	1.13	0.85	1.91	0.52	0.95	0.59
Timp1	1	0.87	0.25	0.55	0.26	0.39	0.79