Analysis of Acrolein Exposure Induced Pulmonary Response in Seven Inbred Mouse Strains and Human Primary Bronchial Epithelial Cells Cultured at Air-Liquid Interface

Table 2

Summary of transcript level changes in oxidative stress, proinflammatory, and tissue injury markers in lung tissue collected from seven mouse strains after subchronic inhalation exposure to acrolein. Numbers indicate the fold change level compared to controls exposed to filtered air.

Mouse strains	Oxidative stress markers					Proinflammatory markers					Tissue injury/repair markers
	Gpx1	Gpx3	Hmox1	Nfkb1	Sod3	Cxcl1	Cxcl2	IL-6	IL-17B	Tnfα	Mmp9	Timp1
BALB/cByJ	2.3	2.9	1.7	2.7	1.9	2.3	1.9	2.9	2.7	1.7	2.31	1.1
C57BL/6J	5.6	3.3	1.8	2.8	3.4	3.5	2.8	3.6	3.9	2.3	1.68	2
129S1/SvImJ	1.7	1.6	1.1	2.2	1.5	2.9	1.8	4.7	3.7	1.8	1.1	1.7
DBA/2J	2.1	1.8	1.4	0.8	0.9	0.5	1.2	0.7	1.1	0.9	1.9	3
C3H/HeJ	2.4	2.8	0.9	1.1	4.7	1.4	1.3	1.1	1.5	1.2	2.0	4.6
A/J	1.5	2.3	1.3	1.9	0.9	1.5	1.3	2.4	1.9	2.5	0.9	1.8
FVB/NJ	1.9	1.9	0.9	0.82	1.2	2.9	2.9	0.9	1.7	1.1	1.6	3.0

Glutathione peroxidase 1 (Gpx1), Gpx3; heme oxygenase 1 (Hmox1); superoxide dismutase 3, extracellular (Sod3); nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 (Nfkb1); chemokine (C-X-C motif) ligand 1 (Cxcl1), Cxcl2 (aka: macrophage inhibitor protein/ Mip2); interleukin-6 (IL-6), IL-17B; tumor necrosis factor alpha (Tnfα); matrix metallopeptidase 9 (Mmp9); tissue inhibitor of metalloproteinase 1 (Timp1).