The Role of Overexpressed Apolipoprotein AV in Insulin-Resistant Hepatocytes

Table 1

The biological function and pathways significantly related with differentially expressed genes.

	Category	Term	Count	value
Up	BP	GO:0072332∼intrinsic apoptotic signaling pathway by p53 class mediator	4	3.37E − 03
		GO:0008283∼cell proliferation	10	1.77E − 02
		GO:0000278∼mitotic cell cycle	11	1.85E − 02
	CC	GO:0030672∼synaptic vesicle membrane	5	3.26E − 03
		GO:0008021∼synaptic vesicle	6	3.65E − 03
		GO:0031225∼anchored component of membrane	6	7.74E − 03
	MF	GO:0005544∼calcium-dependent phospholipid binding	5	3.06E − 03
		GO:0030276∼clathrin binding	4	1.65E − 02
		GO:0042802∼identical protein binding	13	2.68E − 02
	Pathway	hsa04110:cell cycle	6	6.48E − 03
		hsa05222:small cell lung cancer	4	4.75E − 02
		hsa05215:prostate cancer	4	4.89E − 02
Down	BP	GO:0007267∼cell-cell signaling	1.60E + 01	8.96E − 05
		GO:0007155∼cell adhesion	1.90E + 01	9.76E − 04
		GO:0070370∼cellular heat acclimation	3.00E + 00	2.07E − 03
	CC	GO:0005576∼extracellular region	65	6.66E − 11
		GO:0005887∼integral component of plasma membrane	51	8.76E − 07
		GO:0016324∼apical plasma membrane	19	6.89E − 06
	MF	GO:0005319∼lipid transporter activity	4	3.08E − 03
		GO:0008083∼growth factor activity	10	3.32E − 03
		GO:0046982∼protein heterodimerization activity	19	3.90E − 03
	Pathway	hsa05322:systemic lupus erythematosus	9	5.29E − 03
		hsa02010:ABC transporters	5	1.12E − 02
		hsa05134:legionellosis	5	2.25E − 02
		hsa04080:neuroactive ligand-receptor interaction	12	2.27E − 02
		hsa05034:alcoholism	9	2.53E − 02
		hsa04975:fat digestion and absorption	4	4.25E − 02

Up, upregulated genes; down, downregulated genes; BP, biological process; CC, cellar component; MF, molecular function.