The Role of Overexpressed Apolipoprotein AV in Insulin-Resistant Hepatocytes

Table 4

Altered GO function and pathways for genes in significant modules.

	Category	Term	Count	value
Module 1	BP	GO:0007200∼phospholipase C-activating G-protein coupled receptor signaling pathway	5	7.25E − 09
		GO:0007204∼positive regulation of cytosolic calcium ion concentration	4	2.29E − 05
		GO:0007186∼G-protein coupled receptor signaling pathway	5	4.98E − 04
	CC	GO:0005887∼integral component of plasma membrane	9	8.82E − 10
		GO:0005886∼plasma membrane	9	5.52E − 06
		GO:0016324∼apical plasma membrane	3	6.78E − 03
	MF	GO:0045028∼G-protein coupled purinergic nucleotide receptor activity	2	6.29E − 03
		GO:0004435∼phosphatidylinositol phospholipase C activity	2	1.35E − 02
		GO:0004930∼G-protein coupled receptor activity	3	3.65E − 02
	Pathway	hsa04080:neuroactive ligand-receptor interaction	8	1.57E − 10
		hsa04020:calcium signaling pathway	4	5.22E − 04
Module 2	BP	GO:0006334∼nucleosome assembly	11	6.08E − 20
		GO:0006325∼chromatin organization	6	4.58E − 07
		GO:0032776∼DNA methylation on cytosine	4	1.76E − 06
	CC	GO:0000786∼nucleosome	10	2.64E − 19
		GO:0000788∼nuclear nucleosome	4	2.69E − 06
		GO:0005654∼nucleoplasm	10	3.98E − 06
	MF	GO:0046982∼protein heterodimerization activity	9	1.97E − 10
		GO:0042393∼histone binding	6	1.26E − 08
		GO:0003677∼DNA binding	10	5.40E − 08
	Pathway	hsa05322:systemic lupus erythematosus	9	1.47E − 13
		Hsa05034:alcoholism	9	1.42E − 12
		hsa05203:viral carcinogenesis	5	8.52E − 05

GO, gene ontology; BP, biological process; CC, cellar component; MF, molecular function.