Recombinant Lactococcus lactis Expressing Ling Zhi 8 Protein Ameliorates Nonalcoholic Fatty Liver and Early Atherogenesis in Cholesterol-Fed Rabbits
Table 1
Effects of oral recombinant Lactococcus lactis in high cholesterol diet of rabbits on body weight and serum parameters.
Measurement
Sham
VO
LZ8
W0
W3
W5
W0
W3
W5
W0
W3
W5
Body weight (Kg)
2.62 ± 0.32
2.75 ± 0.25
2.79 ± 0.26
2.38 ± 0.30
2.51 ± 0.23
2.61 ± 0.38
2.58 ± 0.25
2.72 ± 0.29
2.83 ± 0.23
Cholesterol (mg/dL)
38 ± 8.6
1264 ± 214
1487 ± 552
41.5 ± 22.9
831.3 ± 511.3
1342 ± 258
39.3 ± 8.1
1390 ± 602
1980 ± 394.7
HDL-chol (mg/dL)
19 ± 5.8
30 ± 7.9
31.5 ± 11.2
14.2 ± 4.9
39.2 ± 11.9
26.5 ± 11.7
20.5 ± 4.7
29.25 ± 8.7
21.8 ± 5.6
LDL-chol (mg/dL)
8.5 ± 3.6
527.9 ± 80.9
540.8 ± 237.5
9.85 ± 7.9
291.3 ± 198.8
520.5 ± 96.1
7.05 ± 2.2
558.1 ± 262.3
773.2 ± 121.9
Triglyceride (mg/dL)
56.5 ± 14.5
89.5 ± 68.3
111.5 ± 52.8
44 ± 14.6
79.8 ± 58.5
71.3 ± 28.7
45.8 ± 5.3
79 ± 44.0
110.8 ± 64.9
AST (U/L)
24.2 ± 9.1
348.5 ± 156.9
107.5 ± 57.1
18 ± 5.6
179.5 ± 40.9
52 ± 25.5
36 ± 18.9
83.3 ± 73.8
73.2 ± 29.2
ALT (U/L)
44.3 ± 22.6
304 ± 94.2
134 ± 59.7
33.5 ± 5.8
183.7 ± 58.7
78.5 ± 25.8
54 ± 22.8
84.3 ± 47.9
98.3 ± 57.5
HDL, high-density lipoproteins; LDL, low-density lipoproteins; AST, aspartate aminotransferase; ALT, alanine aminotransferase.Values are means ± SD of 4 rabbits from each group. The statistics show comparisons between W0 and W3 or W0 and W5 from each group by the Bonferroni multiple range test. ; ;.
