Association of Leptin Gene Polymorphisms with Rheumatoid Arthritis in a Chinese Population

Table 2

Genotype and allele frequencies of leptin gene in RA patients and controls.

SNP	Analyzed model	RA patients [ (%)]	Control [ (%)]	value	OR (95% CI)
rs10244329	Genotype
	AA	332 (55.80)	341(56.93)	0.255	0.765 (0.481-1.215)
	AT	228 (38.32)	211(35.23)	0.689	0.689 (0.428-1.109)
	TT	35 (5.88)	47(7.85)	Reference
	Allele
	A	892 (74.96)	893 (74.54)	0.815	0.978 (0.813-1.177)
	T	298 (25.04)	305(25.46)	Reference
	Dominant model
	AA	332 (55.80)	341 (56.93)	0.694	1.047 (0.833-1.316)
	TT+AT	263 (44.20)	258 (43.07)	Reference
	Recessive model
	AA+AT	560 (94.12)	552 (92.15)	0.180	0.734 (0.467-1.155)
	TT	35 (5.88)	47 (7.85)	Reference
rs2071045	Genotype
	CC	194 (32.61)	203 (33.89)	0.992	1.002 (0.723-1.387)
	CT	289 (48.57)	279 (46.58)	0.614	0.924 (0.680-1.256)
	TT	112 (18.82)	117 (19.53)	Reference
	Allele
	C	677 (56.89)	685 (57.18)	0.887	1.012 (0.860-1.190)
	T	513 (43.11)	513 (42.82)	Reference
	Dominant model
	CC	194 (32.61)	203 (33.89)	0.638	1.060 (0.833-1.348)
	TT+CT	401 (67.39)	396 (66.11)	Reference
	Recessive model
	CC+CT	483 (81.18)	482 (80.47)	0.756	1.047 (0.785-1.396)
	TT	112 (18.82)	117 (19.53)	Reference
rs2167270	Genotype
	GG	366 (61.51)	374 (62.44)	0.285	0.743 (0.431-1.282)
	GA	205 (34.45)	192 (32.05)	0.178	0.681 (0.389-1.194)
	AA	24 (4.03)	33 (5.51)	Reference
	Allele
	G	937 (78.74)	940 (78.46)	0.870	0.984 (0.809-1.196)
	A	253 (21.26)	258 (21.54)	Reference
	Dominant model
	GG	366 (61.51)	374 (62.44)	0.742	1.040 (0.823-1.314)
	AA+GA	229 (38.49)	225 (37.56)	Reference
	Recessive model
	GG+GA	571 (96.67)	566 (94.49)	0.232	0.721 (0.412-1.235)
	AA	24 (4.03)	33 (5.51)	Reference

CI: confidence interval; OR: odds ratios; : number; : single nucleotide polymorphism.