Research Article
Association of Leptin Gene Polymorphisms with Rheumatoid Arthritis in a Chinese Population
Table 3
Associations of leptin gene polymorphisms with risk of different serotypes of RA.
| | SNP | Clinical features | | Genotype [ (%)] | value | Allele [ (%)] | value | | Allele (M/m) | Group | MM | Mm | mm | | M | m | |
| | rs10244329 (A/T) | Anti-CCP | Positive | 270 (55.44) | 186 (38.19) | 31 (6.37) | 0.583 | 726 (74.54) | 248 (25.46) | 0.314 | | Negative | 45 (60.81) | 26 (35.14) | 3 (4.05) | | 116 (78.38) | 32 (21.62) | | | RF | Positive | 262 (54.60) | 187 (39.04) | 30 (6.26) | 0.319 | 711 (74.22) | 247 (25.78) | 0.129 | | Negative | 61 (62.89) | 32 (32.99) | 4 (4.12) | | 154 (79.38) | 40 (20.62) | | | rs2071045 (C/T) | Anti-CCP | Positive | 159 (32.65) | 232 (47.64) | 96 (19.71) | 0.215 | 550 (56.47) | 424 (43.53) | 0.825 | | Negative | 21 (28.38) | 43 (58.11) | 10 (13.51) | | 85 (57.43) | 63 (42.57) | | | RF | Positive | 153 (31.94) | 232 (48.43) | 94 (19.63) | 0.607 | 538 (56.16) | 420 (43.84) | 0.351 | | Negative | 34 (35.05) | 48 (49.48) | 15 (15.46) | | 116 (59.79) | 78 (40.21) | | | rs2167270 (G/A) | Anti-CCP | Positive | 294 (60.37) | 173 (35.52) | 20 (4.11) | 0.973 | 761 (78.13) | 213 (21.87) | 0.234 | | Negative | 52 (70.27) | 18 (24.32) | 4 (5.41) | | 122 (82.43) | 26 (17.57) | | | RF | Positive | 290 (60.54) | 168 (35.07) | 21 (4.39) | 0.373 | 748 (78.08) | 210 (21.92) | 0.179 | | Negative | 66 (68.04) | 28 (28.87) | 3 (3.09) | | 160 (82.47) | 34 (17.53) | |
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M: major alleles; m: minor alleles; : number; SNP: single nucleotide polymorphism. |
