Noninvasive Prediction of TERT Promoter Mutations in High-Grade Glioma by Radiomics Analysis Based on Multiparameter MRI
Table 1
Characteristics of patients in the training and validation cohorts.
Training cohort
Validation cohort
value
TERTw
TERTm
value
TERTw
TERTm
value
51
37
22
16
0.995
Age (year)
53 (18-78)
58 (30-81)
0.033
52 (26-78)
60 (42-80)
0.031
0.986
Gender
0.571
0.120
0.975
Female
19 (37.25%)
16 (43.24%)
11 (50.00%)
4 (25.00%)
Male
32 (62.75%)
21 (56.76%)
11 (50.00%)
12 (75.00%)
Grade
0.170
0.366
0.327
III
21 (41.18%)
10 (27.03%)
7 (31.82%)
3 (18.75%)
IV
30 (58.82%)
27 (72.97%)
15 (68.18%)
13 (81.25%)
Side
0.384
0.050
0.219
Left
27 (52.94%)
15 (40.54%)
17 (77.27%)
7 (43.75%)
Right
20 (39.22%)
20 (54.05%)
3 (13.64%)
8 (50.00%)
Both
4 (7.84%)
2 (5.41%)
2 (9.09%)
1 (6.25%)
Location
0.048
0.028
0.421
Frontal
23 (45.10%)
7 (18.92%)
8 (36.36%)
1 (6.25%)
Temporal
16 (31.37%)
23 (62.16%)
4 (18.18%)
11 (68.75%)
Parietal
7 (13.73%)
3 (8.11%)
4 (18.18%)
2 (12.50%)
Occipital
2 (3.92%)
2 (5.41%)
2 (9.09%)
1 (6.25%)
Other
3 (5.88%)
2 (5.41%)
4 (18.18%)
1 (6.25%)
NeV
0.42 (0.00-2.59)
0.86 (0.04-4.44)
0.243
0.41 (0.00-2.61)
0.95 (0.08-4.05)
0.102
0.559
EnV†
2.62 (0.02-41.70)
1.93 (0.03-37.17)
0.715
3.02 (0.20-28.36)
1.97 (0.11-9.99)
0.115
0.633
EdV†
1.31 (0.01-56.46)
2.88 (0.03-37.17)
0.162
1.16 (0.04-65.77)
2.15 (0.45-17.06)
0.856
0.827
CNV (%)
14.71 (0.00-40.44)
43.48 (14.91-84.49)
<0.001
14.38 (0.00-38.38)
37.64 (11.54-71.20)
<0.001
0.264
ONV (%)
12.44 (0.00-39.55)
15.42 (4.55-29.16)
0.196
6.75 (0.00-32.33)
17.98 (1.76-28.18)
0.091
0.197
Cho/NAA
4.65 (3.14)
4.40 (1.89)
0.670
4.22 (1.51)
4.80 (2.79)
0.413
0.868
Cho/Cr
2.75 (1.06)
3.39 (1.53)
0.023
2.54 (0.68)
3.19 (1.04)
0.025
0.390
Lip
0.616
0.152
0.944
No
33 (64.71%)
22 (59.46%)
16 (72.73%)
8 (50.00%)
Yes
18 (35.29%)
15 (40.54%)
6 (27.27%)
8 (50.00%)
Lac
0.025
0.034
0.370
No
33 (64.71%)
15 (40.54%)
17 (77.27%)
7 (43.75%)
Yes
18 (35.29%)
22 (59.46%)
5 (22.73%)
9 (56.25%)
Data were the median(min-max); the remainder were mean (standard deviation) or number (%). value <0.05 was considered a significant difference. NeV: necrotic volume of tumor; EnV: volume of enhanced portion of tumor; EdV: volume of edema around tumor; CNV: necrotic volume percentage of core; ONV: necrotic volume percentage of overall; Cho/NAA: the ratio of N-acetylaspartic acid to creatine in MRS; Cho/Cr: the ratio of choline to creatine in MRS; Lip: lipid peak of MRS; Lac: lactate peak of MRS; TERTm: the TERT promoter mutations; TERTw: the wild type of TERT promoter.
