Noninvasive Prediction of TERT Promoter Mutations in High-Grade Glioma by Radiomics Analysis Based on Multiparameter MRI

Table 3

Univariate and multivariate analyses of TERT promoter mutations.

	Univariate		Multivariate
	OR (95% CI)	value	OR (95% CI)	value
Age	1.04 (1.00, 1.08)	0.038	1.06 (1.01, 1.12)	0.025
Gender	0.78 (0.33, 1.85)	0.571
Grade	1.89 (0.76, 4.72)	0.173
Side	2.00 (0.33, 12.18)	0.452
Location	2.19 (0.30, 15.85)	0.437
NeV	1.38 (0.80, 2.35)	0.245
EnV	0.99 (0.93, 1.05)	0.712
EdV	1.04 (0.98, 1.11)	0.197
CNV (%)	1.15 (1.09, 1.22)	<0.001	1.12 (1.06 1.18)	<0.001
ONV (%)	1.04 (0.98, 1.10)	0.196
Cho/NAA	0.96 (0.82, 1.14)	0.668
Cho/Cr	1.48 (1.04, 2.09)	0.028	2.71 (1.15, 3.25)	0.012
Lip	1.25 (0.52, 2.99)	0.616
Lac	2.69 (1.12, 6.43)	0.026	3.14 (1.01, 9.74)	0.048
Radscore	2.72 (1.78, 4.14)	<0.001	2.04 (1.51, 2.77)	<0.001

OR: odds ratios; CI: confidence intervals; NeV: necrotic volume of tumor; EnV: volume of enhanced portion of tumor; EdV: volume of edema around tumor; CNV: necrotic volume percentage of core; ONV: necrotic volume percentage of overall; Cho/NAA: the ratio of N-acetylaspartic acid to creatine in MRS; Cho/Cr: the ratio of choline to creatine in MRS; Lip: lipid peak of MRS; Lac: lactate peak of MRS; Radscore: radiomics feature. value <0.05 was considered significant difference.