Overexpression of Sphingosine Kinase-1 and Sphingosine-1-Phosphate Receptor-3 in Severe Plasmodium falciparum Malaria with Pulmonary Edema

Figure 1

Representative images of immunoperoxidase staining for SphK-1 and S1PR-3 in the lung tissues of severe P. falciparum malaria patients. (a, b) Normal lung tissues. (c, d) Lung tissues of severe P. falciparum malaria patients without PE. (e, f) Lung tissues of severe P. falciparum malaria patients with PE. Green arrowheads indicate alveolar type II cell. Yellow arrowheads indicate alveolar type I cell. Red arrowheads indicate endothelial cells. Purple arrowheads indicate alveolar macrophage. Green asterisks indicate the lumen of the blood vessel. All images were acquired at 400x magnification. .