Natural Products: Review for Their Effects of Anti-HBV

Table 1

The compounds with anti-HBV effects from natural products.

No.	Compound	Target	Source	Ref
1	6-Hydroxyl-7-methoxyl-coumarin	HBsAg and HBeAg	S. asper	[19]
2	Esculetin	HBsAg, HBeAg, and HBV-DNA	M. fortunei	[20]
3	Magnatriol B	HBsAg and HBeAg	S. asper	[21]
4	Honokiol	HBsAg and HBeAg	S. asper	[21]
5	Isomagnolol	HBsAg	S. asper	[22, 23]
6	isocarpine	HBsAg	S. asper	[22, 23]
7	Honokiol		S. asper	[22, 23]
8	(7R, 8S, 7R, 8S)-erythron-Strebluslignanol G	HBsAg, HBeAg, and HBV-DNA	S. asper	[22, 23]
9	Coumarin lignan	HBsAg and HBeAg	K. heteroclita	[24]
10	Niranthin	HBsAg and HBeAg	P. niruri	[25]
11	(+)-Dehydrod-iconiferyl alcohol	HBsAg	S. patens	[26]
12	Dehydrozingerone	HBsAg	S. patens	[26]
13	(+)-Cycloolivil-4-O-β-D-glucopyranoside	HBsAg, HBeAg, and HBV-DNA	S. chirayita	[27]
14	Syringaresinol 4-O-β-D-glucopyranoside	HBsAg	S. chirayita	[27]
15	Luteolin	HBsAg and HBeAg	S. macrosperma	[29]
16	Isovitexin	HBsAg, HBeAg, and HBV-DNA	S. yunnanensis	[30]
17	LPRP-Et-97543	Core, S, and preS promoters	L. muscari	[31]
18	Quercetin	HBeAg		[32]
19	Glabaarachalcone	HBV-DNA	P. pinnata	[33]
20	Isopongachromene	HBV-DNA	P. pinnata	[33]
21	Isooriention	HBsAg, HBeAg, and HBV-DNA	S. mussotii	[34]
22	Epimedium Hyde II	HBsAg, HBeAg, and HBV-DNA		[35]
23	Norbellidifolin	HBV-DNA	S. mussotii	[36]
24	1,5,8-Trihydroxy-3-methoxyxanthone	HBsAg and HBeAg	S. mussotii	[36]
25	2-C-β-D-glucopyranosyl-1,3,7-trihydroxyxanthone	HBsAg and HBeAg	S. mussotii	[36]
26	Norswertianolin	HBV-DNA	S. mussotii	[36]
27	Norswertianin-1-O-β-D-glucoside	HBV-DNA	S. mussotii	[36]
28	1,7-Dihydroxy-3,8-dimethoxyxanthone	HBV-DNA	S. mussotii	[36]
29	7-O-[β-D-xylopyranosyl-(1→2)-β-D-xylopyranosyl]-1,8-dihydroxy-3-methoxyxanthone	HBV-DNA	S. mussotii	[36]
30	Mangiferin	HBV-DNA	S. mussotii	[36]
31	Methyl6,8-dihydroxy-3-methyl-9-oxo-9H-xanthene-1-carboxylate	HBsAg	Penicillium sp.	[37]
32	1,8-Dihydroxy-3,5-dimethoxyxanthone	HBsAg, HBeAg, and HBV-DNA	S. yunnanensis	[30]
33	Norswertianolin	HBV-DNA	S. yunnanensis	[30]
34	Neolancerin	HBsAg, HBeAg, and HBV-DNA	S. yunnanensis	[30]
35	1,5,8-Trihydroxy-3-methoxyxanthone	HBeAg and HBV-DNA	S. delavayi	[38]
36	(−)-2R-1-hydroxyisorhodoptilometrin	HBsAg and HBeAg	Penicillium sp.	[37]
37	Asterric acid	HBsAg	Penicillium sp.	[37]
38	Questinol	HBsAg	Penicillium sp.	[37]
39	Endocrocin	HBsAg	Penicillium sp.	[37]
40	(+)-2S-isorhodoptilometrin	HBsAg	Penicillium sp.	[37]
41	Sulochrin	HBsAg	Penicillium sp.	[37]
42	Monochlorsulochrin	HBsAg and HBeAg	Penicillium sp.	[37]
43	Dihydrogeodin	HBsAg	Penicillium sp.	[37]
44	1,3-Dihydroxy-2-hydroxymethyl-9,10-anthraquinone	HBeAg and HBsAg	P. connata	[40]
45	Rubiadin	HBeAg, HBsAg, HBx, and HBV-DNA	P. connata	[40]
46	Anthraquinone bile acid conjugates	HBeAg and HBsAg	P. connata	[40]
47	Aloin B	HBV-DNA polymerase	Aloe vera	[41]
48	Aloe-emodin	CYP3A4	Aloe vera	[41]
49	Hypericin	HBsAg, HBeAg, HBV-DNA, and pgRNA		[42]
50	Ursolic acid	HBsAg and HBeAg	S. asper	[19]
51	MH	HBsAg and HBeAg	V. tenuifolia	[44]
52	Sweriyunnangenin A	HBsAg and HBeAg	S. yunnanensis	[26]
53	3-Epitaraxerol	HBsAg and HBeAg	S. yunnanensis	[26]
54	Oleanolic acid	HBsAg and HBeAg	S. yunnanensis	[26]
55	Erythrocentaurin	HBsAg, HBeAg, and HBV-DNA	S. yunnanensis	[26]
56	Astataricusones B	HBeAg, HBV-DNA, and HBsAg	A. tataricus	[45]
57	Epishionol	HBeAg and HBV-DNA	A. tataricus	[45]
58	Astershionones C	HBsAg, HBeAg, and HBV-DNA	A. tataricus	[46]
59	4-Hydroxy-3-methoxyalbiflorin	HBsAg, HBeAg, and HBV-DNA	P. sinjiangensis	[47]
60	6-O-p-hydroxybenzoyl-4-Hydroxyalbiflorin	HBsAg, HBeAg, and HBV-DNA	P. sinjiangensis	[47]
61	Albiflorin	HBsAg, HBeAg, and HBV-DNA	P. sinjiangensis	[47]
62	Oxypaeoniflorin	HBsAg, HBeAg, and HBV-DNA	P. sinjiangensis	[47]
63	Paeoniflorin	HBsAg, HBeAg, and HBV-DNA	P. sinjiangensis	[47]
64	Paeonins B	HBsAg, HBeAg, and HBV-DNA	P. sinjiangensis	[47]
65	Benzoylpaeoniflorin	HBsAg, HBeAg, and HBV-DNA	P. sinjiangensis	[47]
66	Perovskatone A	HBsAg	P. atriplicifolia	[48]
67	Demethylsalvicanol	HBsAg	P. atriplicifolia	[48]
68	Chrysanolide B	HBsAg and HBeAg	D. indicum	[49]
69	Chrysanolide C	HBsAg and HBeAg	D. indicum	[49]
70	Chrysanolide A	HBsAg and HBeAg	D. indicum	[49]
71	Pimelotide A	HBsAg	P. elongata foliage	[50]
72	Wikstroelide W	HBV-DNA	W. chamaedaphne	[51]
73	Genkwanine P		W. chamaedaphne	[51]
74	laurifolioside A		W. chamaedaphne	[51]
75	2-Epi-laurifolioside A	HBV-DNA	W. chamaedaphne	[51]
76	Laurifolioside B	HBV-DNA	W. chamaedaphne	[51]
77	2-Epi-laurifolioside B	HBV-DNA	W. chamaedaphne	[51]
78	Laurifolioside	HBV-DNA	W. chamaedaphne	[51]
79	2-epi-laurifolioside	HBV-DNA	W. chamaedaphne	[51]
80	Oleanolic acid 3-O-β-D-glucuronopyranoside	HBV-DNA	A.philoxeroides	[52]
81	4,5-Dihydroblumenol	HBV-DNA	A.philoxeroides	[52]
82	Swericinctosides A	HBV-DNA and HBsAg	S. cincta	[53]
83	Swericinctoside B	HBV-DNA	S. cincta	[53]
84	9-Epi swertiamarin	HBV-DNA and HBsAg	S. cincta	[53]
85	2-O-m-hydroxybenzoyl swertiamarin	HBV-DNA	S. cincta	[53]
86	4-O-actyl swertianoside E	HBV-DNA and HBsAg	S. cincta	[53]
87	Swertiaside	HBV-DNA and HBsAg	S. cincta	[53]
88	Swertianoside C	HBV-DNA and HBsAg	S. cincta	[53]
89	Decentapicrin B	HBV-DNA	S. cincta	[53]
90	ET derivatives 1e	HBV-DNA	Synthesis	[54]
91	ET derivatives 1f	HBV-DNA	Synthesis	[54]
92	Swertiakoside A	HBV-DNA	S. delavayi	[38]
93	2-O-acetylswertiamarin	HBV-DNA	S. delavayi	[38]
94	Asiaticoside	HBsAg, HBeAg, and HBV-DNA	H. sibthorpioides	[55]
95	Diosgenin	HBsAg and HBeAg		[56]
96	7-Eudesm-4(15)-ene-1β,6α-diol	HBV-DNA	A. capillaris	[57]
97	Pumilaside A	HBeAg, HBsAg, and HBV-DNA	A. capillaris	[57]
98	Erythro-1-[1-oxo-9(3,4-methylenedioxyphenyl)-8,9-dihydroxy-2E-nonenyl]-piperidine	HBsAg and HBeAg	P. longum	[59]
99	Threo-1-[1-oxo-9(3,4-methylenedioxyphenyl)-8,9-dihydroxy-2E-nonenyl]-piperidine	HBsAg and HBeAg	P. longum	[59]
100	Piperine	HBsAg and HBeAg	P. longum	[59]
101	Guineesine	HBsAg and HBeAg	P. longum	[59]
102	(2E,4E)-N-isobutyleicosa-2,4-dienamide	HBsAg and HBeAg	P. longum	[59]
103	3β,4α-dihydroxy-1-(3-phenylpropanoyl)-piperidine-2-one	HBsAg and HBeAg	P. longum	[60]
104	DHCH	HBsAg, HBeAg, cccDNA, and DNA	C. saxicola	[61]
105	8S-deca-9-en-4,6-diyne-1,8-diol	HBsAg, HBeAg, and HBV-DNA	A. capillaris	[63]
106	(S)-deca-4,6,8-triyne-1,3-diol	HBsAg, HBeAg, and HBV-DNA	A. capillaris	[63]
107	(S)-3-hydroxyundeca-5,7,9-triynoic acid	HBsAg, HBeAg, and HBV-DNA	A. capillaris	[63]
108	3S-Hydroxyundeca-5,9-triynoic acid 3-O-β-D-glucopyranoside	HBsAg, HBeAg, and HBV-DNA	A. capillaris	[63]
109	Atractylodin	HBsAg, HBeAg, and HBV-DNA	A. capillaris	[63]
110	Dendroarboreol B	HBsAg, HBeAg, and HBV-DNA	A. capillaris	[63]
111	Dehydrofalcarinol	HBsAg, HBeAg, and HBV-DNA	A. capillaris	[63]
112	Dehydrofalcarindiol	HBsAg, HBeAg, and HBV-DNA	A. capillaris	[63]
113	(E)-deca-2-en-4,10-diol	HBsAg, HBeAg, and HBV-DNA	A. capillaris	[63]
114	(Z)-deca-2-en-4,10-diol	HBsAg, HBeAg, and HBV-DNA	A. capillaris	[63]
115	8-Diol 1-O-β-D-glucopyranoside	HBsAg, HBeAg, and HBV-DNA	A. capillaris	[63]
116	3S,8S-dihydroxydec-9-ene-4,6-diyne1-O-β-D-glucopyranoside	HBsAg, HBeAg, and HBV-DNA	A. capillaris	[63]
117	5-Benzylthiophencarboxylic acid	HBsAg, HBeAg, and HBV-DNA	A. capillaris	[63]
118	2-Methyl-6-phenyl-4H-pyran-4-one	HBsAg, HBeAg, and HBV-DNA	A. capillaris	[63]
119	3S,8S-dihydroxydec-9-en-4,6-yne 1-O-(6-O-caffeoyl)-β-D-glucopyranoside	HBsAg, HBeAg, and HBV-DNA	A. capillaris	[64]
120	3S,8S-dihydroxydec-9-en-4,6-yne1-O-(2-O-caff-eoyl)-β-D-glucopyranoside	HBsAg, HBeAg, and HBV-DNA	A. capillaris	[64]
121	m-Hydroxybenzoic acid	HBsAg, HBeAg, and HBV-DNA	S. mussotii	[34]
122	p-Hydroxybenzoic acid	HBsAg, HBeAg, and HBV-DNA	S. mussotii	[34]
123	m-Hydroxy benzenmethanol	HBsAg, HBeAg, and HBV-DNA	S. mussotii	[34]
124	3,4-Dihydroxybenzoic acid	HBsAg, HBeAg, and HBV-DNA	S. mussotii	[34]
125	Ethyl 3,4-dihydroxybenzoate	HBsAg, HBeAg, and HBV-DNA	S. mussotii	[34]
126	Ethyl 2,5-dihydroxybenzoate	HBsAg, HBeAg, and HBV-DNA	S. mussotii	[34]
127	3,3,5-Trihydroxybiphenyl	HBeAg	S. chirayita	[27]
128	TaraffinisosideA	HBsAg and HBeAg	T. affinis	[65]
129	Descaffeoyl crenatoside	HBsAg and HBeAg	T. affinis	[65]
130	3,4-Dihydroxyphenylethanol-8-O-[β-D-apiofuranosyl (1→3)]-β-D-glucopyranoside	HBsAg and HBeAg	T. affinis	[65]
131	p-Hydroxy acetophenone (PHAP)	HBsAg	A. morrisonensis	[66]
132	p-HAP derivative 2f	HBV-DNA	A. capillaris	[67]
133	Matijin-Su	HBV-DNA	D. repens	[68]
134	N-[N-(3,4-dimethoxy-benzoyl)-L-phenylalanyl]-O-propionyl-L-phenylalaninol	HBV-DNA	Synthesis	[71]
135	N-[N-(3,4-dimethoxy-benzoyl)-L-phenylalanyl]-4-ethoxy-L-phenylalaninol	HBV-DNA	Synthesis	[71]
136	N-[N-(3,4-Dimethoxy-benzoyl)-L-phenylalanyl]-4-ethoxycarbonylmethyl-L-tyrosinol	HBV-DNA	Synthesis	[71]
137	N-[N-(4-chlorobenzoyl)-O-methyl-L-tyrosyl]-L-Phenylalaninol	HBV-DNA	Synthesis	[72]
138	N-[N-(4-chlorobenzoyl)-O-propyl-L-tyrosyl]-L-Phenylalaninol	HBV-DNA	Synthesis	[72]
139	N-[N-(4-chlorobenzoyl)-O-isopropyl-L-tyrosyl]-L-Phenylalaninol	HBV-DNA	Synthesis	[72]
140	N-[N-(3-trifluoromethylbenzoyl)-L-tyrosyl]-L-Phenylalaninol	HBV-DNA	Synthesis	[73]
141	N-[N-(3-trifluoromethylbenzoyl)-L-phenylalanyl]-O-propionyl-L-tyrosine methyl ester	HBV-DNA	Synthesis	[73]
142	N-[N-(3-trifluoromethylbenzoyl)-L-phenylalanyl]-O-ethyl-L-tyrosine	HBV-DNA	Synthesis	[73]
143	Compound 8n	HBV-DNA	Synthesis	[74]
144	Compound 8o	HBV-DNA	Synthesis	[74]
145	Compound 9 a	HBV-DNA	Synthesis	[75]
146	Compound 9 b	HBV-DNA	Synthesis	[75]
147	Compound 9 c	HBV-DNA	Synthesis	[75]
148	Cyclic (glycine-L-proline)	HBsAg, HBeAg, and HBV-DNA		[76]
149	Cyclic (4-hydroxy proline-phenylalanine)	HBsAg, HBeAg, and HBV-DNA		[76]
150	Cyclic (L-2-hydroxy proline-phenylalanine)	HBsAg, HBeAg, and HBV-DNA		[76]
151	N-acetyl phenylalanine	HBsAg and HBeAg	P. crinitum	[77]
152	Two dimers of oxanthrone	HBsAg, HBeAg, and HBV-DNA	S. punicea	[78]
153	Iridoid lactone	HBsAg, HBeAg, and HBV-DNA	S. punicea	[78]
154	Anislactone B	HBeAg	I. henryi	[79]
155	NC-8	HBsAg and HBeAg	Synthesis	[80]
156	IN-4	HBV-DNA	Synthesis	[81]
157	Scoparamide A	HBsAg, HBeAg, and HBV-DNA	A. scoparia	[64]
158	Cichoric acid	DHBV-DNA	C. intybus	[82]
159	Rosmarinic acid	ε-Pol binding		[83]
160	3-Caffeoylquinicacid	HBsAg, HBeAg, and HBV-DNA	L. japonica	[84]
161	Cryptochlorogenic acid	HBV-DNA	L. japonica	[84]
162	Neochlorogenic acid	HBV-DNA	L. japonica	[84]
163	3,5-Dicaffeoylquinic acid	HBsAg, HBeAg, and HBV-DNA	L. japonica	[84]
164	4,5-Dicaffeoylquinic acid	HBsAg, HBeAg, and HBV-DNA	L. japonica	[84]
165	3,4-Dicaffeoylquinic acid	HBsAg, HBeAg, and HBV-DNA	L. japonica	[84]