Long Noncoding RNA MALAT1 Promotes Colorectal Cancer Progression by Acting as a ceRNA of miR-508-5p to Regulate RAB14 Expression

Figure 5

MALAT1 functions as the sponge of miR-508-5p in CRC cells. (a) Predicted binding sites in MALAT1 for miR-508-5p. (b) miR-508-5p mimics decreased the luciferase activity of the MALAT1-WT group. (c) MALAT1 inhibition increased miR-508-5p expression in SW480 and HCT-8 cells. (d) RIP assay revealed that the enrichment of MALAT1 was highly elevated by miR-508-5p overexpression in SW480 and HCT-8 cells. (e) MALAT1 expression was inversely associated with miR-508-5p expression in CRC tissues. (f, g) miR-508-5p mimics rescued the effects of MALAT1 overexpression on HCT-8 cell proliferation and invasion. .

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