Long Noncoding RNA MALAT1 Promotes Colorectal Cancer Progression by Acting as a ceRNA of miR-508-5p to Regulate RAB14 Expression

Figure 6

MALAT1 knockdown suppresses RAB14 expression by interacting with miR-508-5p. (a) Predicted binding sites in 3UTR-RAB14 for miR-508-5p. (b) miR-508-5p mimics decreased the luciferase activity of the WT-RAB14 group. (c) miR-508-5p mimics increased miR-508-5p levels in SW480 and HCT-8 cells. (d) miR-508-5p overexpression reduced RAB14 protein expression in SW480 and HCT-8 cells. (e, f) miR-508-5p mimics abolished the effects of MALAT1 overexpression on RAB14 expression in SW480 and HCT-8 cells. .

(a)

(b)

(c)

(d)

(e)

(f)