In Vivo Imaging of Neutrophil Extracellular Traps (NETs): Visualization Methods and Outcomes

Figure 1

Mechanisms of NET formation. Upon activation, phenomenal morphological changes are observed during suicidal NETosis, which is followed by cell rupture and subsequent cell death. Contrarily, in vital NETosis, NETs are released rapidly by the active and functional NET-releasing neutrophils through blebbing of the nuclear envelope and vesicular exportation.