Full-Length TrkB Variant in NSCLC Is Associated with Brain Metastasis

<div>Immunohistochemical detection of TrkB and BDNF protein expression in section samples obtained by Group 1 (ADK with brain metastasis). (a) The histograms summarize the results obtained. A statistical significant increase of TrkB and BDNF protein expression was observed in samples from metastasis compared with relative primitive ADKs. (b) Notice the anatomical localization of BDNF and TrkB protein expression in ADK cells. A strong specific immunostaining was clearly documented in both primitive ADKs and brain metastasis (a–d). 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BioMed Research International

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Figure 3

Figure 3: Full-Length TrkB Variant in NSCLC Is Associated with Brain Metastasis 