PLP2 Expression as a Prognostic and Therapeutic Indicator in High-Risk Multiple Myeloma

Figure 1

PLP2 was a high-risk myeloma gene. (a) PLP2 expression of NPC (), MGUS (), SMM (), and MM (TT2, ; TT3, ) in GSE5900 and GSE2658 datasets (, ). (b) A scatter plot showing the PLP2 expression in eight MM subgroups (CD1 and CD2 subgroups with spiked expression of CCND1 and CCND3; PR: proliferation; LB: low-bone disease; HY: hyperdiploid; MS: MMSET; MF: MAFB; MY: myeloid). (c) CD138 and PLP2 expressions in the bone marrow of NDMM patients. Representative case with a lack of PLP2 expression: H&E stain, CD138 immunostain, and PLP2 immunostain (upper row). Representative case with stable PLP2 expression: H&E stain, CD138 immunostain, and PLP2 immunostain (lower row).

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