L-Arginine Ameliorates High-Fat Diet-Induced Atherosclerosis by Downregulating miR-221

Figure 2

L-arginine prevents oxidized low-density lipoprotein (OxLDL)-induced apoptosis in endothelial cells. Representative FACS plots of Annexin V fluorescein isothiocyanate (FITC)/propidium iodide (PI) stained endothelial cells treated with OxLDL or cotreated with OxLDL and L-arginine at different concentrations for 24 h. (a) Blank group. (b) OxLDL-treated group. (c) 5 mM L-arginine group. (d) 25 mM L-arginine group. (e) 50 mM L-arginine group.

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