L-Arginine Ameliorates High-Fat Diet-Induced Atherosclerosis by Downregulating miR-221

Figure 3

Expression of microRNA-221 (miR-221) after L-arginine treatment in atherosclerosis (AS) rat models and endothelial cells. (a) Relative expression of miR-221 and endothelial nitric oxide synthase (eNOS) in AS rat models. compared to the high-fat group; compared to the blank group. (b) Relative expression of miR-221 in endothelial cells. compared to the oxidized low-density lipoprotein-treated group (OxLDL); compared to the blank group. (c) Relative expression of eNOS in AS rat models. compared to the high-fat group; compared to the blank group. (d) Relative expression of eNOS in endothelial cells. compared to the OxLDL-treated group; compared to the blank group.

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