Molecular Epidemiology and Clinical Features Analysis of Respiratory Adenovirus Infections Reveals Correlations between Genotype, Inflammatory Biomarkers, and Disease Severity
Table 2
Demographics and clinical features of hospitalized children with adenovirus infection.
Characteristic
All patients ()
Nonsevere infection ()
Severe infection ()
Male sex
40 (71.4)
20 (71.4)
1.00
Median age, month (range)
33.7 (4.8-111)
16.1 (3.2-58.7)
0.001
Fever duration days (range)
6.7 (1-21)
12.9 (3-34)
<0.001
Median peak temperature, °C
0.175
Respiratory symptoms
Cough
43 (76.8)
26 (92.8)
0.07
Rhinorrhea
18 (32.1)
5 (17.8)
0.166
Tachypnea/dyspnea
12 (21.4)
22 (78.6)
<0.001
Pleural effusion
3 (5.3)
15 (53.6)
<0.001
Rales
29 (51.8)
28 (100)
<0.001
Laboratory tests
WBC, ×109 cells/l
0.307
> cells/l
15 (26.8)
6 (21.4)
0.593
CRP, mg/l (IQR)
29 (44.3–4.6)
47.9 (63-18)
0.032
>0.15 mg/l
54 (96.4)
28 (100)
0.311
>40 mg/l
14 (25)
12 (42.8)
0.095
PCT, ng/ml (IQR)
0.77 (0.72–0.11)
4.39 (4.07–0.87)
<0.001
>0.05 ng/ml
51 (91.1)
27 (96.4)
0.658
>0.5 ng/ml
18 (32.2)
24 (85.7)
<0.001
Outcomes
Hospitalized duration days (range)
10.2 (3 - 36)
20.2 (3 - 84)
<0.001
Intensive care required
21 (37.5)
26 (92.8)
<0.001
Mechanical ventilation
None
15 (53.6)
<0.001
Death
None
4 (14.3)
<0.001
Values are no. (%) of patients or , unless otherwise indicated. Range: extreme values at both ends; IQR: interquartile range; WBC: whole blood cell; CRP: C-reactive protein; PCT: procalcitonin.
