The miR-582/CD1B Axis Is Involved in Regulation of Dendritic Cells and Is Associated with Clinical Outcomes in Advanced Lung Adenocarcinoma

Figure 5

Relationships between miR-582 and CD1B expression and immune cell types. Patients were stratified according to miR-582 and CD1B expression. The different fractions of immune cell subtypes were then compared using Kruskal-Wallis tests (a, b). Patients were stratified into high and low categories based on the median expression level of CD1B for Kaplan-Meier survival analysis by OS, and the results were determined based on the independent gene profile microarray GSE31210 (c). Pearson correlation coefficients between CD1B and various checkpoint molecules (PDCD1, CTLA4, LAG3, and HAVCR2) were calculated (d). The regulation of miR-583 and CD1B was predicted by TargetScanHuman (e).

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