Mesenchymal Stem Cell-Specific and Preosteoblast-Specific Ablation of TSC1 in Mice Lead to Severe and Slight Spinal Dysplasia, Respectively

Figure 3

Micro-CT and bone density of WT, Prrx1-TSC1 null, and BGLAP-TSC1 null mice. (A1-A2, B1-B2, C1-C2) Micro-CT three-dimensional reconstruction and bone density of spine in WT and Prrx1-TSC1 null mice. (A3-A4, B3-B4, C3-C4) Micro-CT three-dimensional reconstruction and bone density of spine in WT and BGLAP-TSC1 null mice. (D) Statistical analysis of VB height in WT, Prrx1-TSC1 null, and BGLAP-TSC1 null mice. (E) Statistical analysis of BMD in WT, BGLAP-TSC1, and Prrx1-TSC1 null mice. (F) Statistical analysis of TB-N in WT, BGLAP-TSC1, and Prrx1-TSC1 null mice. (G) Statistical analysis of BV/TV in WT and Prrx1-TSC1 null mice. (H) Statistical analysis of Tb-Th in WT and Prrx1-TSC1 null mice. (, “” represents ; “” represents ; “” represents ).