Chemerin: A Potential Regulator of Inflammation and Metabolism for Chronic Obstructive Pulmonary Disease and Pulmonary Rehabilitation

Figure 3

Summary of ways in which chemerin affects glucose and lipid metabolism. (a) Roles of chemerin in glucose metabolism. Chemerin is expressed in pancreatic beta cells and regulates glucose metabolism via effects on insulin synthesis and insulin resistance. Additionally, the effect of chemerin on gluconeogenesis is one of its mechanisms. (b) Roles of chemerin in lipid metabolism and adipogenesis. Firstly, chemerin stimulates the conversion of BMSC to adipocytes. Secondly, chemerin indirectly stimulates lipid metabolism by enhancing the blood supply of adipose tissue in a chronic low-level inflammatory environment. Abbreviation: NEs: neutrophils; Mφ: macrophages; NKs: natural killer cells; BMSC: bone marrow mesenchymal stem cells; GLUT2: glucose transporter 2.

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