Review Article

Chemerin: A Potential Regulator of Inflammation and Metabolism for Chronic Obstructive Pulmonary Disease and Pulmonary Rehabilitation

Table 1

Summary of studies on the regulation of chemerin by exercise.

Study IDDesignSample sizeParticipantsInterventionChemerin levelOther findings related to chemerin changes

Malin et al. [146]Prospective clinical trialTotal: 30Older obesity adultsComponents: treadmill walking and cycle ergometer exercise
Frequency and duration: 5 days/wk; 60 minutes/day; 12 wks
Intensity: 85% of MHR
Decreased chemerin compared to the baseline ( vs.  ng/ml; )BW (, ); total body fat (, ); VF (, ); TC (, ); triglyceride concentrations (, ); first-phase and total GSIS (, and , )

Aghapour and Farzanegi [165]Quasiexperimental research with a pre-post testTotal: 20
EG (); CG ()
Hypertensive postmenopausal womenEG
 Components: warm-up, main training exercises, and cool-down exercises
 Frequency and duration: 3 times a wk; 60 minutes/day; 6 wks
 Intensity: 50% MHR and 5% was added every 2 wks
CG did not participate in any training program
Decreased chemerin level compared to the baseline ( vs.  pg/ml; )

Faramarzi et al. [148]Clinical controlled trialTotal: 35
EG (); CG ()
Overweight womenEG
 Components: warm-up, rhythmic AE, core stability training, cooling processes
 Frequency and duration: 3 times a wk; 80 minutes/day; 12 wks
 Intensity: 30 at 55% of heart rate reserve and progressed to 80% of heart rate
CG did not participate in any training program
A significant difference in serum chemerin level in EG vs. CG ( vs. .43 mg/dl; )BMI, WC, body fat, insulin, and IR also show the significant difference in the comparison (EG vs. CG)

Stefanov et al. [144]Clinical controlled trialTotal: 56
EG (); CG ()
Overweight or obese individualsEG
 Components: AE, RE, and flexibility exercises
 Frequency and duration: 2 times a wk, 30-35 min/day (1-10 wk); 3 times a wk, 45-60 min/day (11-20 wk); 4 times a wk, 45-60 min/day (21-24 wk)
 Intensity: AE at 50-60% of the MHR; RE for the major muscle groups in two sets of 8-14 repetitions (1-10 wk); AE at 60-75% of MHR; RE in three sets of 8-14 repetitions (11-24 wk)
CG: usual care and education
Chemerin decreased significantly from baseline within the exercise group (post-pre) (ng/ml, ).WC (r = 0.34, ); fat mass (, ); fat-free mass (, ); HOMA-IR (, ); LDL cholesterol (, )

Neuparth et al. [166]Cross-sectional and retrospective studyTotal: 83
Active group: 30
Sedentary group: 51
Type 2 diabetes mellitus patientsActive group
 Components: walking exercise
 Frequency and duration: three times a wk, at least 30 min/day, 1 year
 Intensity: moderate
Chemerin level in active group vs. sedentary group (134 (102-181) vs. 181 (156-199) ng/ml, )BMI, body weight, and oxidized LDL also show a significant difference in the comparison (active group vs. sedentary group)

Venojarvi et al. [145]Randomized controlled trialTotal: 144
Nordic walking group (); resistance training group (); CG ()
Overweight and obese menNordic walking group
 Components: warm-up, AE, cool-down
 Frequency and duration: 3 times a wk, 60 min/day,
 Intensity: 55% to 75% of MHR
Resistance training group
 Components: warm-up, RE, cool-down
 Frequency and duration: 3 times a wk, 60 min/day, 12 wks
 Intensity: 50%-85% from exercise-specific maximal strength (5RM)
CG had no supervised exercise
Both exercise groups downregulated serum chemerin (post-pre) compared to CG (-1.6 (2.7), -1.1 (3.8), and 8.1 (2.6) μg/ml)TC, fatty liver index, LDL cholesterol, BW, leptin, and fat percentage decreased in Nordic walking group (vs. CG)

Kim et al. [167]Randomized controlled trialTotal: 35
EG (); CG ()
Overweight or obese subjects with type 2 diabetesEG
 Components: AE; RE (warm-up, core exercises, resistance training, cool-down)
 Frequency and duration: 2-3 times a wk, 30-40 min/day (AE); 3 times a wk, 50 min/day (RE); 12 wks
 Intensity: 50-70% of the MHR (AE); 3 sets of 20 repetitions at 50% 10RM (RE)
CG: usual care and education
A significant decrease (post-pre) was showed in the comparison between the exercise vs. control groups ( vs.  ng/ml, )ISI (, ); lipocalin-2 (, ); FPG (, ); TC (, )

Saremi et al. [142]Randomized controlled trialTotal: 21
EG (); CG ()
Overweight and obese subjectsExercise group
 Components: warm-up, treadmill walking-running, relaxation exercises
 Frequency and duration: 5 days a wk, 50-60 min/day, 12 wks
 Intensity: 15-20 min at 60-65% of HRmax (wk 1); 25-30 min at 60-70% of MHR (wk 2-3); 35-40 min at 75-80% of MHR (wk 4-7); 45-50 min at 80–85% of MHR (wk 8-12)
CG: usual lifestyle
A significant decrease was showed in the comparison between two groups ()VF (, ), subcutaneous fat (, ), HOMA-IR (, ), glucose (, ), WC (, ), and VO2 peak (, )

Kim et al. [143]Randomized controlled trialTotal: 47
CG (); RE group (); combined exercise group ()
Healthy elderly participantsRE group
 Components: leg extension, pull weight, chair pull, cool down
Frequency and duration: 3 days a wk, 70 min/day, 6 wks
 Intensity: Borg scale 6 (1-2 wks); Borg scale 7 (3-4 wks); Borg scale 8 (5-6 wks)
Combined exercise group
 Components: leg extension, pull weight, chair pull, sky-walk, cross-country, cool down
 Frequency and duration: 3 days a wk, 90 min/day, 6 wks
 Intensity: Borg scale 6 (1-2 wks); Borg scale 7 (3-4 wks); Borg scale 8 (5-6 wks)
CG: usual care
A significant reduction in chemerin level (post-pre) in combined exercise group vs. CG ( vs.  ng/ml)Significant reductions in fasting insulin and HOMA-IR were observed in the combined exercise group

Supriya et al. [168]Randomized controlled trialTotal: 97
CG (); yoga groups ()
Individuals with metabolic syndrome and high-normal blood pressureYoga group
 Components: warm-up, hatha yoga practice, cool-down
 Frequency and duration: once a wk, 60 min/once, 1 year
 Intensity: —
CG: contacted monthly to monitor their health status
Significant reduction in chemerin level was observed in the yoga group vs. the control groupSignificant reduction in WC was observed in yoga vs. CG

Data are presented as , means (SE), or median values (interquartile ranges). EG = exercise group; CG = control group; AE = aerobic exercises; RE = resistance exercise; MHR = maximum heart rate; wk = week; VF = visceral fat; TC = total cholesterol; GSIS = glucose-stimulated insulin secretion; BMI = body mass index; BW = body weight; WC = waist circumstance; IR = insulin resistance; HOMA-IR = insulin resistance index of homeostasis model assessment; ISI = insulin sensitivity index; FPG = fasting plasma glucose.