Preclinical Development of Mahanine-Enriched Fraction from Indian Spice Murraya koenigii for the Management of Cancer: Efficacy, Temperature/pH stability, Pharmacokinetics, Acute and Chronic Toxicity (14-180 Days) Studies

Table 8

Maximum tolerated dose (MTD) of MEF_M2.

Dose (mg/kg/day), fed for 14 days	Weight (grams) on the day of treatment	Weight (grams) after 14 days	Behavioral patterns, activity during feeding period
Control			Normal
300			Normal
500			Normal
750			Normal
1000			Normal
1500			Slightly inactive

Normal Balb/c mice were fed for 14 days to determine MTD. Body weights are represented by . There are no significant () differences between the control and treated mice.