Research Article
Peptidomics Analysis Discloses That Novel Bioactive Peptides Participate in Necrotizing Enterocolitis in a Rat Model
Table 1
Differential peptides in the intestine tissue of NEC rat model.
| Accession | Gene | Peptide | Fold change | value |
| Upregulated peptides | G3V8B3 | Hist1h2bq | AVTKYTSSK | 57.72612 | <0.05 | P69897 | Tubb5 | FVFGQSGAGNN | 31.84287 | <0.01 | Q10758 | Krt8 | DGKLVSESSDIMSK | 25.55914 | <0.001 | Q10758 | Krt8 | LVSESSDIMSK | 22.05736 | <0.001 | P15999 | Atp5a1 | VGLKAPGIIPR | 21.49717 | <0.001 | O88989 | Mdh1 | VIVVGNPANTNCLTASK | 12.14385 | <0.05 | Q66HT1 | Aldob | ALQASALAAWGGK | 11.93121 | <0.001 | G3V8B3 | Hist1h2bq | LLLPGELAKH | 11.86002 | <0.001 | P04182 | Oat | ALQDPNVAAF | 11.16052 | <0.05 | P05197 | Eef2 | VFSGVVSTGLKVR | 10.57569 | <0.05 | Q10758 | Krt8 | QPGFGSVGGSST | 10.57101 | <0.01 | F1LNF1 | Hnrnpa2b1 | GFGFVTF | 10.55872 | <0.05 | K7S2S2 | Hist2h2aa3 | AGLQFPVGR | 10.3368 | <0.05 | Q7M0E3 | Dstn | FLWAPEQAPLKSK | 10.01604 | <0.01 | Q10758 | Krt8 | GGLTSPGFS | 9.126557 | <0.001 | M0R7B4 | Hist1h1d | SGVSLAALKK | 8.945185 | <0.001 | Q10758 | Krt8 | FQPGFGSVGGSST | 8.793551 | <0.001 | P69897 | Tubb5 | FVFGQSGAGN | 8.771316 | <0.05 | D3ZGY4 | Gapdh-ps2 | GAAQNIIPASTGAAKAVGK | 8.399639 | <0.001 | D3ZBN0 | Hist1h1b | SLVSKGTLVQTK | 8.352781 | <0.01 | M0R7B4 | Hist1h1d | GILVQTKGTGASGS | 8.334644 | <0.001 | P02262 | NA | VGAGAPVYL | 8.301511 | <0.001 | Q10758 | Krt8 | GMSSFQPGFGSVGGSST | 8.18755 | <0.01 | P10719 | Atp5b | IGLFGGAGVGK | 7.935978 | <0.01 | B5DEM5 | Rpl14 | AAIAAAAAAK | 7.751116 | <0.01 | K7S2S2 | Hist2h2aa3 | GLQFPVGR | 7.629358 | <0.05 | P62630 | Eef1a1 | ESFSDYPPLGR | 7.607978 | <0.001 | O55159 | Epcam | QKDCVCNNYKLTSR | 7.485879 | <0.001 | P15865 | Hist1h1e | SETAPAAPAAPAPAEKTPIKKK | 7.38236 | <0.01 | D3ZGY4 | Gapdh-ps2 | VKVGVNGFGR | 7.332894 | <0.001 | F1M577 | LOC100359671 | AFIAHPKLGK | 6.954795 | <0.05 | Q6P725 | Des | TFGGAPGFSLGSPLS | 6.720618 | <0.05 | G3V8B3 | Hist1h2bq | LLLPGELAK | 6.595403 | <0.01 | D3ZIE9 | Aldh18a1 | VGLGGMEAKVK | 6.321181 | <0.001 | Q925G0 | Rbm3 | DYSGSQGGYDRYSGGN | 6.259407 | <0.01 | Q10758 | Krt8 | SFQPGFGSVGGSST | 6.237045 | <0.01 | Q10758 | Krt8 | SSFQPGFGSVGGSST | 6.119025 | <0.01 | Q9QXQ0 | Actn4 | STALYGESDL | 5.964186 | <0.001 | Q10758 | Krt8 | GSLGGFGGAGVGGIT | 5.600793 | <0.05 | P05065 | Aldoa | ALQASALK | 5.474993 | <0.01 | M0RA08 | Plin3 | VTGAVDVTCGAVK | 5.466526 | <0.001 | Q6P9V9 | Tuba1b | VAEITNACFEPAN | 5.315759 | <0.05 | A0A0G2K3Z9 | NA | SSGNAKIGHPAPSFK | 4.969645 | <0.01 | Q66H80 | Arcn1 | VLLAAAVCTK | 4.865557 | <0.05 | D3ZGY4 | Gapdh-ps2 | ALNDNFVK | 4.838244 | <0.05 | B0K031 | Rpl7 | IALTDNSLVAR | 4.834916 | <0.001 | P62268 | Rps23 | KANPFGGASHAK | 4.801351 | <0.001 | D3Z7Y6 | Krt20 | LGVAPSVYGGAGGHGT | 4.677876 | <0.001 | Q10758 | Krt8 | KLEVDPNIQAVR | 4.663074 | <0.001 | D3ZBN0 | Hist1h1b | SLVSKGTLVQTKGTGASGSF | 4.551461 | <0.01 | M0R7B4 | Hist1h1d | SGVSLAALK | 4.443164 | <0.01 | P05197 | Eef2 | VNFTVDQIR | 4.417121 | <0.01 | V5QR27 | NA | FPGQPGGPGA | 4.341792 | <0.05 | P63029 | Tpt1 | LDYREDGVTPF | 4.230072 | <0.05 | Q5EB49 | Eno1 | SFRNPLAK | 4.118444 | <0.05 | Q80ZE7 | Cd2ap | GLPAGGIQPHPQTK | 3.871932 | <0.01 | M0R7B4 | Hist1h1d | ASGPPVSELITK | 3.803902 | <0.001 | P18420 | Psma1 | LVSLIGSK | 3.745425 | <0.05 | P13437 | Acaa2 | GVFIVAAK | 3.727173 | <0.01 | D3ZGY4 | Gapdh-ps2 | GAAQNIIPASTGAAK | 3.718082 | <0.001 | Q10758 | Krt8 | SLGGFGGAGVGGIT | 3.670916 | <0.001 | D3ZBN0 | Hist1h1b | ALAAGGYDVEKNNSR | 3.654154 | <0.05 | Q9WVK7 | Hadh | TGEGFYKYK | 3.578854 | <0.01 | K7S2S2 | Hist2h2aa3 | AGLQFPVGRVH | 3.386712 | <0.05 | A0A0G2K6S9 | Myh11 | STVAALEAK | 3.278155 | <0.01 | P06302 | Ptma | SDAAVDTSSEITTK | 3.185452 | <0.05 | G3V779 | Lad1 | TEVLVTPAGVASK | 3.18017 | <0.01 | B2GVB1 | S100a6 | LIYNEALK | 3.138931 | <0.001 | K7S2S2 | Hist2h2aa3 | AEILELAGNAAR | 3.121051 | <0.01 | P69897 | Tubb5 | YNEATGGKYVPR | 3.110143 | <0.05 | D3Z7Y6 | Krt20 | SLSSSSQGPALSTSGSL | 3.061158 | <0.05 | P63018 | Hspa8 | SKGPAVGIDLGTT | 3.057092 | <0.05 | A0A0G2JWK7 | Tagln | EFTDSQLQEGK | 3.027585 | <0.05 | P62630 | Eef1a1 | QTVAVGVIK | 3.020094 | <0.05 | P21913 | Sdhb | AQTAAAAAPRIK | 2.929567 | <0.01 | Q5RJK6 | Inpp1 | LIQSLGPLKT | 2.899027 | <0.01 | P10860 | Glud1 | VVQGFGNVGLH | 2.760697 | <0.05 | P47875 | Csrp1 | GFGFGQGAGALVH | 2.639933 | <0.001 | Q63191 | Mamdc4 | ADQVTLPESITSNP | 2.631403 | <0.01 | Q07936 | Anxa2 | STVHEILCKL | 2.621438 | <0.001 | P06302 | Ptma | AAVDTSSEITTK | 2.568546 | <0.01 | Q3MHS9 | Cct6a | AAVKTLNPKAEVAR | 2.554117 | <0.05 | P38552 | Lgals4 | YPSAGYNPPQ | 2.508311 | <0.05 | P05197 | Eef2 | VAVEAKNPADLPK | 2.48379 | <0.01 | Q5RKI0 | Wdr1 | SVADGYSENNVF | 2.474195 | <0.001 | G3V8B3 | Hist1h2bq | HAVSEGTKAVTKYTSSK | 2.468693 | <0.05 | Q6URK4 | Hnrnpa3 | YGGGGNYNDFGN | 2.394012 | <0.05 | Q6VPP3 | Clca4 | DTQPVLENFSR | 2.382552 | <0.05 | P12346 | Tf | LLEACTFHKS | 2.333879 | <0.05 | P63029 | Tpt1 | GAIDDSLIGGN | 2.312302 | <0.001 | Q10758 | Krt8 | GGFGGAGVGGIT | 2.276436 | <0.05 | Q07936 | Anxa2 | STVHEILCK | 2.247658 | <0.01 | P00731 | Cpa1 | ALSTDSFNYATYH | 2.173098 | <0.05 | Q6URK4 | Hnrnpa3 | SGSPYGGGYGSGGGSGGYGS | 2.128543 | <0.05 | P38552 | Lgals4 | YPSAGYNPPQMN | 2.11776 | <0.001 | Q4FZY0 | Efhd2 | ATDELASKLSR | 2.05165 | <0.05 | A0A0G2QC04 | Pls1 | EGITAIGGTSSI | 2.004625 | <0.01 | P38552 | Lgals4 | PAYPSAGYNPPQMN | 1.905471 | <0.001 | Q9Z144 | Lgals2 | SEKFEVTNLNMK | 1.899939 | <0.05 | D3ZVN3 | Fbxo10 | HNAEAGVDIR | 1.77112 | <0.05 | G3V779 | Lad1 | QQVVGAVQAPGQEKVE | 1.722176 | <0.01 | P46462 | Vcp | AVANETGAF | 1.668905 | <0.001 | D4A3Z8 | Tmco3 | LRIRPTQSV | 1.649045 | <0.05 | Downregulated peptides | A0A0G2K890 | Ezr | FVIKPIDKK | -1.50403 | <0.05 | Q9JJ19 | Slc9a3r1 | EALVEPASESPRPA | -1.52587 | <0.05 | K7S2S2 | Hist2h2aa3 | AQGGVLPNIQAV | -1.53578 | <0.05 | P15865 | Hist1h1e | APAAPAAPAPAEKTP | -1.57197 | <0.001 | F1M4J0 | Rictor | STELLLGV | -1.57785 | <0.05 | A0A0G2JUA5 | Ahnak | DVDVQGPDWH | -1.61943 | <0.01 | Q63191 | Mamdc4 | NADQVTLPESITSNP | -1.64595 | <0.05 | Q6P9V9 | Tuba1b | DLEPTVIDEVR | -1.66594 | <0.05 | B5DFA0 | Vil1 | EENQVITPRLF | -1.69645 | <0.05 | A0A0G2K3K2 | Actb | NELRVAPEEHPV | -1.70784 | <0.05 | Q63191 | Mamdc4 | QVTLPESITSNP | -1.7079 | <0.05 | D3ZDZ1 | Apbb1ip | LPPPPPPP | -1.72276 | <0.01 | Q5EB49 | Eno1 | KLNVVEQEKIDQLMIEMDGTENK | -1.7416 | <0.05 | P62630 | Eef1a1 | GVGEFEAGISKN | -1.78783 | <0.01 | P63269 | Actg2 | FAGDDAPRAVFPS | -1.81415 | <0.001 | D3ZBN0 | Hist1h1b | GTGASGSFKLN | -1.85091 | <0.001 | D3ZAU0 | Muc5b | ITFCEGSCSGK | -1.90446 | <0.05 | P06302 | Ptma | SDAAVDTSSEITTKDL | -1.93122 | <0.05 | D3ZX87 | LOC100910017 | KNLQTVNVDEN | -1.93203 | <0.05 | D3ZUM4 | Glb1 | LELCTVEFVDTPVIG | -1.97941 | <0.01 | Q6P9V9 | Tuba1b | QPPTVVPGGDLAK | -2.01585 | <0.05 | P63312 | Tmsb10 | ADKPDMGEIASFD | -2.02372 | <0.001 | D4A269 | NA | ADEIAKAQVA | -2.02826 | <0.001 | A0A0G2K890 | Ezr | APPPPPPPVYEPVN | -2.10935 | <0.01 | F1LQ48 | Hnrnpl | DEGYGPPPPHYE | -2.13291 | <0.01 | P08081 | Clta | APAGAPGGPALGN | -2.17074 | <0.001 | P06761 | Hspa5 | MKETAEAYLGKK | -2.21256 | <0.01 | Q62803 | Spam1 | LEDDLVNTIGEIV | -2.21478 | <0.05 | P38552 | Lgals4 | IPAYPSAGYNPPQ | -2.21577 | <0.01 | A0A0G2K6S9 | Myh11 | AQKGQLSDDEKF | -2.22383 | <0.05 | P13437 | Acaa2 | SACIGGGQGISLIIQNTA | -2.23257 | <0.01 | P30009 | Marcks | SPEAPPAPVAE | -2.24701 | <0.001 | P45592 | Cfl1 | ASGVAVSDGVIK | -2.24734 | <0.001 | O55212 | NA | DAGAAGGPGGPGGPGLG | -2.30987 | <0.05 | D4AE06 | Fkbp15 | TPSVQPSLQPSHP | -2.32989 | <0.05 | P62630 | Eef1a1 | SGDAAIVDMVPGKP | -2.36181 | <0.001 | P63269 | Actg2 | FAGDDAPRAVFPSIV | -2.37939 | <0.05 | P62630 | Eef1a1 | FAPVNVTTEVK | -2.45167 | <0.01 | P30009 | Marcks | CSPEAPPAPVAE | -2.54825 | <0.01 | A0A0G2K3K2 | Actb | DSGDGVTHTVPIYE | -2.55819 | <0.01 | D3ZFU9 | Mylk | AQPVGALKPIGN | -2.77191 | <0.05 | P15865 | Hist1h1e | SETAPAAPAAPAPAEKTPIK | -2.77847 | <0.001 | Q53Z83 | Mt1 | SCCSCCPVGCSKCAQGCVC | -2.79709 | <0.05 | D3ZDZ1 | Apbb1ip | NFLPPPPPPP | -2.8025 | <0.001 | P63312 | Tmsb10 | ADKPDMGEIAS | -2.84338 | <0.001 | Q6URK4 | Hnrnpa3 | SPYGGGYGSGGGSGGY | -2.93019 | <0.01 | Q10758 | Krt8 | GFGGAGVGGIT | -2.95692 | <0.01 | P62630 | Eef1a1 | VGEFEAGISKN | -2.98559 | <0.001 | D3ZFU9 | Mylk | AKPAETLKPVGN | -2.98675 | <0.01 | A0A0G2K890 | Ezr | APPPPPPPVYE | -3.14377 | <0.001 | Q91W32 | Casp1 | KEGGAFPGPSGSLK | -3.15783 | <0.001 | Q53Z83 | Mt1 | SCCSCCPVGCSKCAQGCVCKG | -3.27655 | <0.01 | P06302 | Ptma | SDAAVDTSSEITTKDLK | -3.51799 | <0.001 | B6ID08 | Mt2A | SCCSCCPVGCAKCSQGCICK | -3.56818 | <0.05 | Q6P9V9 | Tuba1b | LEPTVIDEVR | -3.6423 | <0.001 | P62630 | Eef1a1 | AGVGEFEAGISKN | -3.79477 | <0.01 | D3ZJF8 | Fcgbp | CVAESTAVCRAQGD | -3.88626 | <0.001 | A0A0G2K890 | Ezr | AELSSEGILDDRN | -3.89919 | <0.05 | A0A0G2JUA5 | Ahnak | EGPEVDVSLP | -4.05973 | <0.01 | Q53Z83 | Mt1 | CAQGCVCKGASDKCTCCA | -4.23021 | <0.01 | Q63041 | A1m | AVDQSVLLLKPEAK | -4.3155 | <0.001 | D3ZBN0 | Hist1h1b | GPPVSEL | -4.64319 | <0.001 | P13668 | Stmn1 | ASSDIQVKELE | -4.88393 | <0.01 | P97881 | Muc13 | GVPSQTSNPYAN | -5.02829 | <0.001 | Q63041 | A1m | ALVQKDTVVKPVIVEPEG | -5.23966 | <0.01 | Q6P9V9 | Tuba1b | TVVPGGDL | -5.71525 | <0.001 | P15865 | Hist1h1e | SETAPAAPAAPAPAEKTP | -6.05552 | <0.001 | Q7M0E3 | Dstn | FLWAPEQAPLK | -6.43258 | <0.01 | P62630 | Eef1a1 | ALPGDNVGFN | -6.78263 | <0.001 | Q5PQK2 | Fus | YPTQPGQGYSQQSN | -8.52323 | <0.05 | Q10758 | Krt8 | FGGAGVGGIT | -8.58147 | <0.001 | P62630 | Eef1a1 | APVNVTTEVK | -13.4474 | <0.001 | P63269 | Actg2 | GQKDSYVGDEAQSKRG | -15.8726 | <0.001 |
|
|