A Phenotypic Characterization of Two Isolates of a Multidrug-Resistant Outbreak Strain of Mycobacterium tuberculosis with Opposite Epidemiological Fitness

Table 2

Global enrichment analysis of differentially accumulated proteins between the Mp and 410 strains.

(a)

Mp
Mycobacterium tuberculosis (REF)		Text box input
GO biological process complete	#	#	Expected	Fold enrichment	+/−	Raw value	FDR	Genes
tRNA aminoacylation for protein translation	20	14	2.26	6.18	+	2.13-06	1.32-04	pheT, asps, alas, SerS, tyrS, lysS1, proS, gltX, leuS, argS, hiss, metG, cysS, valS
Mycolic acid biosynthetic process	12	7	1.36	5.15	+	1.82-03	4.51-02	mmaA2, kasB, inhA, mmaA4, cmaA2, cmaA1, mmaA3
Glutamine metabolic process	20	10	2.26	4.42	+	4.92-04	1.60-02	glnA2, asnB, glnA4, gltB, cobQ, hisH, glmS, pyrG, pknG, guaA
Tricarboxylic acid cycle	25	11	2.83	3.89	+	6.03-04	1.85-05	icd2, gabD1, glcB, citA, gabD2, can, lpdC, sdhA, icd, sdhB, fumC
Ribonucleoside monophosphate biosynthetic process	32	12	3.62	3.31	+	1.07-03	3.02-02	purT, purH, pyrD, purD, purA, purB, add, purr, carB, guaA, purM, prs
Ribonucleoside metabolic process	88	22	9.96	2.21	+	1.92-03	4.54-02	relA, tesB2, purT, pyk, pfkA, purH, pyrD, gpmA, glcB, Rv0386, aceE, purD, coax, lpdC, purA, pyrG, fba, purB, purU, carB, guaA, purM
Nucleotide biosynthetic process	93	23	10.53	2.18	+	1.50-03	4.05-02	ppnK, nrdF2, cmk, relA, purT, dcd, nadD, purH, pyrD, nadE, Rv0386, nrdF1, Rv2488c, purD, coax, purA, pyrG, purB, purU, carB, guaA, purM, prs

(b)

410
Mycobacterium tuberculosis (REF)		Text box input
GO biological process complete	#	#	Expected	Fold enrichment	+/−	Raw value	FDR	Genes
Protein folding	14	5	0.33	15.17	+	5.21-05	1.62-02	groEL2, dnaK, grosS, grpE, hspX
Response to hypoxia	46	15	1.08	13.85	+	2.54-12	5.54-09	groEL2, fdxA, devR, Rv2623, hmp, icl, Rv0569, Rv2005c, narX, acg, Rv2629, hspX, Rv3134c, hrp1
Positive regulation of cellular process	33	6	0.78	7.72	+	2.23-04	4.86-02	dnaK, devR, phoP, lpqH, bpa, hbhA
Response to host immune response	129	11	3.04	3.62	+	3.10-04	6.14-02	fdxA, Eis, desA1, icl, lprA, acg, hspX, lpqH, sodC, Rv1738, hrp1