An Integrated Bioinformatic Analysis of the S100 Gene Family for the Prognosis of Colorectal Cancer

Table 2

Gene Ontology analysis of the S100 genes and their most significantly coexpressed genes in CRC.

Category	Term	Count	%	value	FDR
GOTERM_BP_DIRECT	GO:0006954~inflammatory response	9	17.30769	9.11E-06	0.012361
GOTERM_BP_DIRECT	GO:0006935~chemotaxis	6	11.53846	2.24E-05	0.030396
GOTERM_BP_DIRECT	GO:0018149~peptide cross-linking	4	7.692308	0.000367	0.497246
GOTERM_BP_DIRECT	GO:0070098~chemokine-mediated signaling pathway	4	7.692308	0.001028	1.385837
GOTERM_BP_DIRECT	GO:0007186~G-protein coupled receptor signaling pathway	9	17.30769	0.003201	4.257847
GOTERM_BP_DIRECT	GO:0007204~positive regulation of cytosolic calcium ion concentration	4	7.692308	0.006236	8.138288
GOTERM_CC_DIRECT	GO:0070062~extracellular exosome	22	42.30769	5.91E-06	0.006523
GOTERM_CC_DIRECT	GO:0001533~cornified envelope	4	7.692308	0.000271	0.299178
GOTERM_CC_DIRECT	GO:0005886~plasma membrane	23	44.23077	0.000633	0.696457
GOTERM_CC_DIRECT	GO:0005576~extracellular region	12	23.07692	0.003667	3.973017
GOTERM_CC_DIRECT	GO:0048471~perinuclear region of cytoplasm	6	11.53846	0.027144	26.19097
GOTERM_CC_DIRECT	GO:0005887~integral component of plasma membrane	9	17.30769	0.037498	34.41178
GOTERM_MF_DIRECT	GO:0050786~RAGE receptor binding	7	13.46154	1.99E-13	2.24E-10
GOTERM_MF_DIRECT	GO:0005509~calcium ion binding	15	28.84615	9.3E-09	1.05E-05
GOTERM_MF_DIRECT	GO:0044548~S100 protein binding	4	7.692308	6.44E-06	0.007239
GOTERM_MF_DIRECT	GO:0048306~calcium-dependent protein binding	4	7.692308	0.000634	0.710203
GOTERM_MF_DIRECT	GO:0019959~interleukin-8 binding	2	3.846154	0.008683	9.337967
GOTERM_MF_DIRECT	GO:0035662~Toll-like receptor 4 binding	2	3.846154	0.011561	12.253