Research Article
Interaction of miR-181b and IFNA1 Polymorphisms on the Risk of Systemic Lupus Erythematosus
Table 2
Association between SNPs in miR-181b and IFNA1 and risk of SLE.
| | Polymorphisms | Controls, (%) | SLE, (%) | Adjusted OR (95% CI)† | value |
| | miR-181b rs322931 | | | | | | CC | 310 (72.1) | 257 (63.9) | 1.00 | | | CT | 114 (26.5) | 135 (33.6) | 1.71 (1.16-2.50) | 0.01 | | CT/TT | 120 (27.9) | 145 (36.1) | 1.45 (1.08-1.95) | 0.01 | | C allele | 734 (85.3) | 649 (80.7) | 1.00 | | | T allele | 126 (14.7) | 155 (19.3) | 1.38 (1.07-1.79) | 0.01 | | IFNA1 rs1332190 | | | | | | TT | 220 (51.2) | 199 (49.5) | 1.00 | | | CT | 185 (43.0) | 168 (41.8) | 1.02 (0.77-1.36) | 0.89 | | CT/CC | 210 (48.8) | 203 (50.5) | 1.08 (0.83-1.42) | 0.56 | | T allele | 625 (72.7) | 566 (70.4) | 1.00 | | | C allele | 235 (27.3) | 238 (29.6) | 1.13 (0.91-1.40) | 0.27 | | IFNA1 rs10811543 | | | | | | GG | 260 (60.5) | 250 (62.2) | 1.00 | | | AG | 146 (34.0) | 132 (32.8) | 0.96 (0.71-1.28) | 0.76 | | AG/AA | 170 (39.5) | 152 (37.8) | 0.95 (0.71-1.25) | 0.70 | | G allele | 666 (77.4) | 632 (78.6) | 1.00 | | | A allele | 194 (22.6) | 172 (21.4) | 0.95 (0.75-1.20) | 0.66 |
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SNP: single-nucleotide polymorphism; IFNA1: interferon alpha 1; SLE: systemic lupus erythematosus; OR: odds ratio; CI: confidence interval. †Adjusted by age and gender.
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