Interaction of miR-181b and IFNA1 Polymorphisms on the Risk of Systemic Lupus Erythematosus

Table 3

Stratification analyses of SNPs in miR-181b and IFNA1 and clinical features of SLE.

Variables	miR-181b rs322931 CT/TT vs. CC		IFNA1 rs1332190 CT/CC vs. TT		IFNA1 rs10811543 AG/AA vs. GG
	Adjusted OR^†	value	Adjusted OR^†	value	Adjusted OR^†	value
Malar rash	1.18 (0.75-1.85)	0.47	1.09 (0.71-1.67)	0.70	1.29 (0.82-2.02)	0.26
Photosensitivity	1.18 (0.75-1.85)	0.20	0.61 (0.40-0.91)	0.02	0.78 (0.52-1.19)	0.25
Leucopenia	0.80 (0.53-1.21)	0.30	0.75 (0.51-1.12)	0.16	0.88 (0.59-1.32)	0.54
Anaemia	0.99 (0.66-1.49)	0.96	1.17 (0.79-1.74)	0.43	1.07 (0.71-1.60)	0.76
Complement depression	1.10 (0.71-1.68)	0.67	1.05 (0.69-1.58)	0.83	1.03 (0.67-1.58)	0.89
Renal disorder	1.13 (0.75-1.71)	0.55	1.36 (0.92-2.01)	0.13	1.13 (0.75-1.69)	0.56
Arthritis	0.75 (0.50-1.15)	0.19	0.92 (0.62-1.37)	0.68	1.06 (0.70-1.59)	0.80
ANA	0.87 (0.47-1.62)	0.66	0.85 (0.47-1.52)	0.58	0.71 (0.38-1.34)	0.28
AdsA	1.10 (0.71-1.70)	0.67	1.34 (0.88-2.04)	0.18	1.10 (0.72-1.70)	0.66

SNP: single-nucleotide polymorphism; IFNA1: interferon alpha 1; SLE: systemic lupus erythematosus; OR: odds ratio; CI: confidence interval. ^†Adjusted by age and gender.