Research Article
Interaction of miR-181b and IFNA1 Polymorphisms on the Risk of Systemic Lupus Erythematosus
Table 5
Combined analyses of SNPs in miR-181b and IFNA1 and risk of SLE.
| | Combined genotypes | Controls, (%) | SLE, (%) | OR (95% CI) | value |
| | miR-181b rs322931-IFNA1 rs1332190 | | | | | | rs322931 CC+rs1332190 TT | 166 (38.6) | 195 (48.5) | 1.00 | | | rs322931 CT/TT+rs1332190 TT | 54 (12.6) | 4 (1.0) | 0.06 (0.02-0.18) | | | rs322931 CC+rs1332190 CT/CC | 144 (33.5) | 62 (15.4) | 0.37 (0.26-0.53) | | | rs322931 CT/TT+rs1332190 CT/CC | 66 (15.3) | 141 (35.1) | 1.82 (1.27-2.60) | 0.001 | | miR-181b rs322931-IFNA1 rs10811543 | | | | | | rs322931 CC+rs10811543 GG | 196 (45.6) | 216 (53.7) | 1.00 | | | rs322931 CT/TT+rs10811543 GG | 64 (14.9) | 34 (8.5) | 0.48 (0.31-0.76) | 0.002 | | rs322931 CC+rs10811543 AG/AA | 114 (26.5) | 41 (10.2) | 0.33 (0.22-0.49) | | | rs322931 CT/TT+rs10811543 AG/AA | 56 (13.0) | 111 (27.6) | 1.80 (1.24-2.62) | 0.002 |
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SNP: single-nucleotide polymorphism; IFNA1: interferon alpha 1; SLE: systemic lupus erythematosus; OR: odds ratio; CI: confidence interval.
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