Evaluation of Zhenwu Decoction Effects on CYP450 Enzymes in Rats Using a Cocktail Method by UPLC-MS/MS

Figure 2

UPLC-MS/MS-specific chromatograms of seven probes and glibenclamide in rat plasma: (a) blank plasma; (b) probe substrates and glibenclamide (IS); (c) blank plasma spiked with phenacetin, bupropion, diclofenac, amodiaquine, omeprazole, dextromethorphan, midazolam, and IS (1-8); (d) plasma probe substrates and IS after receiving cocktail substrate solution through tail vein injection.