Evaluation of Zhenwu Decoction Effects on CYP450 Enzymes in Rats Using a Cocktail Method by UPLC-MS/MS

Table 2

Accuracy of seven probe substrates in rat plasma ().

Probe substrates	Mark concentration (ng/mL)	Accuracy, (ng/mL)	RSD (%)
Phenacetin	2		7.59
	4		5.31
	53		4.77
	1050		2.12
Bupropion	2.25		7.49
	4.5		5.65
	35		2.67
	450		3.14
Diclofenac	30		9.17
	60		4.14
	520		5.78
	6750		4.60
Amodiaquine	0.6		11.2
	1.2		8.18
	10		6.58
	75		4.84
Omeprazole	2		7.63
	4		6.36
	63.5		5.25
	1500		4.80
Dextromethorphan	0.8		7.58
	1.6		5.76
	17.9		4.14
	300		2.08
Midazolam	6		7.56
	12		6.20
	104		4.04
	1350		2.14