Evaluation of Zhenwu Decoction Effects on CYP450 Enzymes in Rats Using a Cocktail Method by UPLC-MS/MS

Table 4

Matrix effect of seven probe substrates in rat plasma ().

Mark concentration (ng/mL)	Compounds	Matrix effect (%)	RSD (%)
LQC	Phenacetin		3.63
	Bupropion		2.12
	Diclofenac		3.35
	Amodiaquine		3.38
	Omeprazole		3.54
	Dextromethorphan		2.15
	Midazolam		3.28
MQC	Phenacetin		2.35
	Bupropion		1.77
	Diclofenac		2.49
	Amodiaquine		3.34
	Omeprazole		1.12
	Dextromethorphan		1.61
	Midazolam		3.32
HQC	Phenacetin		2.72
	Bupropion		1.42
	Diclofenac		2.22
	Amodiaquine		3.75
	Omeprazole		1.91
	Dextromethorphan		1.23
	Midazolam		2.65