Evaluation of Zhenwu Decoction Effects on CYP450 Enzymes in Rats Using a Cocktail Method by UPLC-MS/MS

Table 6

Pharmacokinetic parameters of four probe substrates in rat plasma (, ).

	Parameter	NS	ZWD-L	ZWD-M	ZWD-H
Phenacetin	(mg/L·min)
	(mg/L·min)
	(min)
	CL (L/min/kg)
	(L/kg)
Bupropion	(mg/L·min)
	(mg/L·min)
	(min)			^##
	CL (L/min/kg)
	(L/kg)
Amodiaquine	(mg/L·min)
	(mg/L·min)
	(min)			^#
	CL (L/min/kg)
	(L/kg)
Dextromethorphan	(mg/L·min)
	(mg/L·min)
	(min)		^##	^##
	CL (L/min/kg)
	(L/kg)

Compared with NS, ^# and ^##.