A Novel Seventeen-Gene Metabolic Signature for Predicting Prognosis in Colon Cancer

Table 1

Univariate and multivariable Cox regression analyses in colon cancer.

Variable	Univariate analysis		Multivariate analysis
	HR (95% CI)		HR (95% CI)
Training set
Metabolic signature	3.358 (2.506-4.501)	<0.001	3.253 (2.366-4.473)	<0.001
Age	1.029 (1.007-1.053)	0.011	1.040 (1.017-1.063)	<0.001
Gender	1.276 (0.780-2.089)	0.332	1.192 (0.723-1.966)	0.490
Stage	2.176 (1.645-2.877)	<0.001	2.202 (1.630-2.973)	<0.001
External validation set
Metabolic signature	1.174 (1.039-1.262)	<0.001	1.098 (1.015-1.189)	0.020
Age	0.992 (0.983-1.001)	0.070	1.001 (0.992-1.010)	0.832
Gender	1.132 (0.885-1.448)	0.322	1.262 (0.983-1.619)	0.067
Stage	2.871 (2.428-3.396)	<0.001	2.786 (2.341-3.315)	<0.001