Dexrazoxane Protects Cardiomyocyte from Doxorubicin-Induced Apoptosis by Modulating miR-17-5p

Figure 5

Dexrazoxane attenuates doxorubicin mediated cytotoxicity by the regulation of miR-17-5p/PTEN cascade. (a) The expression of miR-17-5p was demonstrated by qPCR in the Con, DOX, DOX+DEX, and DEX groups (). (b,c) Western blotting and average data for PTEN in Con, DOX, DOX+DEX, and DEX groups (). (d–g) Protein level of PTEN, caspase3, cleaved-caspase3, and Bax in Con, DOX, DOX+NC, and DOX+miR-17-5p mimics groups (). (, , ).

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