Review Article
Association between the MMP-1-1607 1G/2G Polymorphism and Osteoarthritis Risk: A Systematic Review and Meta-Analysis
Table 1
Characteristics of the eligible studies included in the meta-analysis.
| | Author | Year | Country | Ethnicity | OA site | Sample | Genotyping method | Surgery | Design | Sample size | Gender (M/F) | Mean age | NOS | | Total size | Case | Control | Case | Control | Case | Control |
| | Barlas | 2009 | Turkey | Caucasian | Keen OA | Blood | PCR-RFLP | No | HCC | 241 | 157 | 84 | 36/121 | 25/59 | 41–86; | 41–75; 52.36.9 | 6 | | Planello | 2011 | Brazil | Caucasian | TMJ OA | Buccal cell | PCR-RLFP | No | PCC | 232 | 115 | 117 | 14/101 | 15/102 | | | 7 | | Abd-Allah | 2012 | Egypt | Caucasian | Keen OA | Blood | PCR-RLFP | No | HCC | 200 | 100 | 100 | 40/60 | 45/55 | 36–66; | 33–67; | 6 | | Lepetsos | 2014 | Greek | Caucasian | Keen OA | Blood | PCR-RLFP | Yes | HCC | 294 | 155 | 139 | 33/122 | 42/97 | | | 8 | | Luo | 2015 | China | Asian | TMJ | Buccal cell | HRMA | Yes | PCC | 391 | 206 | 185 | NA | 26/159 | 16–75; | 16–71; | 6 | | Yang | 2015 | China | Asian | Keen OA | Blood | PCR-RFLP | Yes | PCC | 414 | 207 | 207 | 53/154 | 53/154 | | | 8 | | Geng | 2018 | China | Asian | Keen OA | Blood | PCR-RFLP | No | PCC | 707 | 306 | 401 | 164/142 | 199/202 | | | 7 |
|
|
OA: osteoarthritis; TMJ: temporomandibular joint; PCR-RFLP: polymerase chain reaction-restriction fragment length polymorphism; HRMA: high-resolution melting assay; HCC: hospital-based case-control study; PCC: population-based case-control study; NOS: Newcastle-Ottawa Scale.
|
