Association between the MMP-1-1607 1G/2G Polymorphism and Osteoarthritis Risk: A Systematic Review and Meta-Analysis

Table 3

Overall and subgroup meta-analysis of the association between MMP-1-1607 1G/2G (rs1799750) polymorphism and osteoarthritis risk under genetic models.

Subject		Allelic			Dominant			Recessive			Homozygote			Heterozygote
		(2G vs. 1G)			(2G1G+2G2G vs. 1G1G)			(2G2G vs. 1G1G+1G2G)			(2G2G vs. 1G1G)			(2G1G vs. 1G1G)
		OR (95% CI)			OR (95% CI)			OR (95% CI)			OR (95% CI)			OR (95% CI)
Total		1.232 (0.889, 1.707)	0.21	<0.01	1.203 (0.801, 1.807)	0.373	0.001	1.478 (0.925, 2.6)	0.102	<0.01	1.512 (0.828, 2.761)	0.179	<0.01	1.088 (0.774, 1.529)	0.627	0.028
Ethnicity
Caucasian	4	1.167 (0.627, 2.173)	0.626	<0.01	1.071 (0.483, 2.376)	0.866	0.001	1.408 (0.615, 3.224)	0.418	<0.01	1.342 (0.457, 3.945)	0.593	<0.01	0.985 (0.497, 1.951)	0.965	0.012
Asian	3	1.307 (0.899, 1.900)	0.161	0.002	1.314 (0.843, 2.048)	0.228	0.054	1.588 (0.872, 2.894)	0.131	0.002	1.703 (0.780, 3.716)	0.181	0.002	1.184 (0.850, 1.648)	0.317	0.224
OA site
Keen OA	5	1.122 (0.716, 1.758)	0.615	<0.01	1.140 (0.637, 2.042)	0.659	<0.01	1.222 (0.695, 2.147)	0.486	<0.01	1.270 (0.549, 2.935)	0.576	<0.01	1.144 (0.734, 1.783)	0.552	0.031
TMJ OA	2	1.575 (1.259, 1.972)	<0.01	0.35	1.295 (0.741, 2.263)	0.363	0.139	2.411 (1.658, 3.504)	<0.01	0.757	2.313 (1.341, 3.991)	0.003	0.234	0.938 (0.487, 1.806)	0.847	0.106
Total size
<300	4	1.167 (0.627, 2.173)	0.626	<0.01	1.071 (0.483, 2.376)	0.866	0.001	1.408 (0.615, 3.224)	<0.01	<0.01	1.342 (0.457, 3.945)	0.593	<0.01	0.985 (0.497, 1.951)	0.965	0.224
>300	3	1.307 (0.899, 1.900)	0.161	0.002	1.314 (0.843, 2.048)	0.228	0.054	1.588 (0.872, 2.894)	0.002	0.002	1.703 (0.780, 3.716)	0.181	0.002	1.184 (0.850, 1.648)	0.317	0.028
Design
HCC	3	1.102 (0.453, 2.684)	0.83	<0.01	1.093 (0.358, 3.338)	0.876	<0.01	1.208 (0.420, 3.480)	0.726	<0.01	1.228 (0.251, 5.996)	0.8	<0.01	1.141 (0.499, 2.608)	0.755	0.024
PCC	4	1.323 (0.993, 1.761)	0.06	0.006	1.231 (0.842, 1.800)	0.284	0.06	1.713 (1.054, 2.783)	0.03	0.003	1.704 (0.943, 3.078)	0.077	0.007	1.035 (0.717, 1.494)	0.854	0.105
Age
≥60	3	0.803 (0.457, 1.412)	0.45	<0.01	0.706 (0.295, 1.687)	0.433	0.009	0.815 (0.454, 1.464)	0.494	0.009	0.662 (0.234, 1.876)	0.438	0.003	0.799 (0.419, 1.524)	0.496	0.106
<60	4	1.635 (1.354, 1.974)	<0.01	0.201	1.622 (1.158, 2.271)	0.005	0.113	2.209 (1.718, 2.840)	<0.01	0.523	2.578 (1.798, 3.696)	<0.01	0.249	1.276 (0.868, 1.876)	0.216	0.077

MMP-1: matrix metalloproteinase-1; OA: osteoarthritis; TMJ: temporomandibular joint; HCC: hospital-based case-control study; PCC: population-based case-control study; : value of heterogeneity.